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Glutamate receptor 1

Summary

UniProt ID: P34299
Gene Symbol: glr-1 C06E1.4
Gene ID: 176204
Organism: Caenorhabditis elegans

External Links

PubChem: P34299
Re-Glyco: P34299

Annotation

Keyword: Cell membrane Cell projection Endoplasmic reticulum Endosome Glycoprotein Ligand-gated ion channel Postsynaptic cell membrane Receptor Reference proteome Signal Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
thigmotaxis	IMP	PMID
hyperosmotic response	IMP	PMID PMID
short-term memory	IMP	PMID
feeding behavior	IMP	PMID
associative learning	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of bitter taste

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

nonassociative learning [inference]

habituation

memory [inference]

short-term memory

behavior [inference]

thigmotaxis

learning or memory [inference]

learning [inference]

associative learning

nonassociative learning [inference]

habituation

memory [inference]

short-term memory

locomotory behavior [inference]

adult locomotory behavior

feeding behavior

adult behavior [inference]

adult locomotory behavior

locomotion [inference]

directional locomotion [inference]

forward locomotion

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hyperosmotic response

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response

response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

regulation of locomotion [inference]

positive regulation of locomotion [inference]

regulation of backward locomotion

positive regulation of backward locomotion

regulation of forward locomotion [inference]

positive regulation of forward locomotion

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
plasma membrane	EXP	PMID
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF
ionotropic glutamate receptor complex	ISS	PMID
ionotropic glutamate receptor complex	IPI	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane

synaptic membrane [inference]

postsynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

leading edge membrane [inference]

neuron projection membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

perinuclear endoplasmic reticulum

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GO Term	Evidence Code	Reference
glutamate-gated receptor activity	IDA	PMID
glutamate-gated receptor activity	IEA	GO_REF
AMPA glutamate receptor activity	ISS	PMID
glutamate receptor activity	IBA	GO_REF
enzyme binding	IPI	PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

binding [inference]

protein binding [inference]

enzyme binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

glutamate receptor activity

glutamate-gated receptor activity

AMPA glutamate receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MFSSFSFLNMFGVLFTVFNLTVVQPYPSHIIIKSFGNNEEVSRVALKAMEYTSDHINSRDDVPFKLAFDHRVVEEGAAVSWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTALSNDDHQQQQFGNLFEVSVRPPISELLADFIVHKGWGEVLVLIDPVHASLHLPSLWRHLRTRTNTSVKASMFDLPADEKQFEAYLMQFNMMRNNETNRILIDCASPKRLKKLLINIRSAQFNQANYHYVLANYDFLPYDQEMFQNGNINISGFNIINKDGREYWSLKKHLKTSSSLGGGDDVSVEAAVGHDAMLVTWHGFAKCLQANDSLFHGTFRHRRFFNRGFPGIYCDPLSDRSHPNRPFSSFEHGKTIGVAFRNMKIGHKEGTLTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAWRQGVGFFSNRTVAQHSRKSQNDHKDNQVIVLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLLADKIEEFNYEIKLGTKAGSKQADGSWDGMIGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEWRVEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGELKKLENKWWYDRGQCDAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIEARKSNSNSMVANFAKNLKSALSSQLRLSVEGGAVAQPGSQSHNAIRRQQVAAFLPANEKEAFNNVDRPANTLYNTAV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	Source
190	N-linked (GlcNAc...) asparagine	UniProt
220	N-linked (GlcNAc...) asparagine	UniProt
275	N-linked (GlcNAc...) asparagine	UniProt
333	N-linked (GlcNAc...) asparagine	UniProt
441	N-linked (GlcNAc...) asparagine	UniProt
482	N-linked (GlcNAc...) asparagine	UniProt
852	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Activation of AMPA receptors	Caenorhabditis elegans
COPII-mediated vesicle transport	Caenorhabditis elegans
Cargo concentration in the ER	Caenorhabditis elegans
Synaptic adhesion-like molecules	Caenorhabditis elegans
Unblocking of NMDA receptors, glutamate binding and activation	Caenorhabditis elegans

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1289	neurodegenerative disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements