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Thyroid peroxidase

Summary

UniProt ID: P35419
Gene Symbol: Tpo
Gene ID: 22018
Organism: Mus musculus (house mouse)

External Links

PubChem: P35419
Re-Glyco: P35419

Annotation

Keyword: Calcium Disulfide bond EGF-like domain Glycoprotein Heme Hydrogen peroxide Reference proteome Signal Sushi Thyroid hormones biosynthesis Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
thyroid hormone generation	IEA	GO_REF GO_REF
response to oxidative stress	IEA	GO_REF
embryonic hemopoiesis	ISO	GO_REF
embryonic hemopoiesis	IEA	GO_REF
hormone biosynthetic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

catabolic process [inference]

hydrogen peroxide catabolic process

biosynthetic process [inference]

hormone biosynthetic process

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
mitochondrion	HDA	PMID
cell surface	ISO	GO_REF
membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	Reference
iodide peroxidase activity	IEA	GO_REF GO_REF GO_REF
peroxidase activity	IBA	GO_REF
peroxidase activity	IEA	GO_REF
calcium ion binding	IEA	GO_REF
heme binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

haloperoxidase activity [inference]

iodide peroxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

halogenase activity [inference]

haloperoxidase activity [inference]

iodide peroxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

haloperoxidase activity [inference]

iodide peroxidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRTLGAMAIMLVVMGTVIFLSFILRSRDILCGKTMKSHVISAVETSQLMVDHAVYNTMKRNLKKREVLSPAQLLSFFKLPESTSGAISRAAEIMETSIQVMKREQSQFSTDALSADILGTIANLSGCLPFMLPPRCPDTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSGTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLPFATAACAPEPGTPRTNRTPCFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQDFESCEDIPSMDLELWRETFPQDDKCVFPEEVDNGNFVHCEESGKLVLVYSCFHGYKLQGQEQVTCTQKGWDSEPPVCKDVNECADLTHPPCHPSAQCKNTKGSFQCVCTDPYVLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLTWIVICRWTHADKKATLPITERVTTQSGCRKSQGRGISPHKAAAQDTGQEPASGSRVLLCE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
123	N-linked (GlcNAc...) asparagine	UniProt
271	N-linked (GlcNAc...) asparagine	UniProt
299	N-linked (GlcNAc...) asparagine	UniProt
334	N-linked (GlcNAc...) asparagine	UniProt
603	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Thyroxine biosynthesis	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	Alliance of Genome Resources

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements