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Insulin receptor substrate 1

Summary

UniProt ID

P35570

Gene Symbol

Irs1
Irs-1

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P35570
PubChem: P35570
The O-GlcNAc Database: P35570
O-GlcNAcAtlas: P35570

Annotation

Keyword

3D-structure
Direct protein sequencing
Phosphoprotein
Reference proteome
Repeat
S-nitrosylation
Transducer
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 31 in total

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GO Term
insulin receptor signaling pathway
regulation of gene expression
epithelial cell migration
lipid catabolic process
cell migration
cytokine-mediated signaling pathway
mammary gland development
cellular response to insulin stimulus
positive regulation of phosphorylation
positive regulation of epithelial cell migration

Displaying **all 8** entries
GO Term
cytoplasm
plasma membrane
insulin receptor complex
intracellular membrane-bounded organelle
cytosol
caveola
ciliary basal body
nucleus

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GO Term
protein-containing complex binding
protein kinase binding
protein domain specific binding
phosphotyrosine residue binding
protein-macromolecule adaptor activity
transmembrane receptor protein tyrosine kinase adaptor activity
protein kinase C binding
insulin receptor binding
insulin-like growth factor receptor binding
signaling receptor complex adaptor activity

Annotation information from UniProt.

Sequence

MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRTKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPNGHYILSRGGNGHRYIPGATMGTSPALTGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVVSIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDSSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSCSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSVTHPHHHALQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCLPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRVGPAPPGAASICRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKVSLPRTTGAAPPPSSTASASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAANTVSFGAGAAGGGSGGGSEDVKRHSSASFENVWLRPGDLGGASKESAPGCGAAGGLEKSLNYIDLDLVKDVKQHPQDCPSQQQSLPPPPPHQPLGSNEGSSPRRSSEDLSTYASINFQKQPEDRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	GlyTouCan ID	Source
914	G49108TO	GlyGen The O-GlcNAc Database
1009	G49108TO	GlyGen
1036	G49108TO	GlyGen The O-GlcNAc Database
1041	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
IRS activation	Rattus norvegicus
IRS-mediated signalling	Rattus norvegicus
IRS-related events triggered by IGF1R	Rattus norvegicus
Interleukin-7 signaling	Rattus norvegicus
PI3K Cascade	Rattus norvegicus
PI3K/AKT Signaling	Rattus norvegicus
PI3K/AKT activation	Rattus norvegicus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Rattus norvegicus
RAF/MAP kinase cascade	Rattus norvegicus
SOS-mediated signalling	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

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Annotation

International Collaboration

Acknowledgements