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Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

Summary

UniProt ID: P37287
Gene Symbol: PIGA
Gene ID: 5277
Organism: Homo sapiens (human)

External Links

PubChem: P37287
The Human Metabolome Database: HMDBP00941
Re-Glyco: P37287

Annotation

Keyword: Alternative splicing Disease variant Endoplasmic reticulum Epilepsy GPI-anchor biosynthesis Glycoprotein Glycosyltransferase Intellectual disability Lipid metabolism Phosphoprotein Proteomics identification Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	Reference
GPI anchor biosynthetic process	TAS	Reactome
GPI anchor biosynthetic process	IBA	GO_REF
GPI anchor biosynthetic process	IEA	GO_REF GO_REF
cellular response to leukemia inhibitory factor

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IDA	PMID
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IBA	GO_REF
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IPI	PMID
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IEA	GO_REF
endoplasmic reticulum membrane	TAS	Reactome

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

endoplasmic reticulum protein-containing complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

catalytic complex [inference]

transferase complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	Reference
UDP-glycosyltransferase activity	TAS	Reactome
phosphatidylinositol N-acetylglucosaminyltransferase activity	TAS	PMID
phosphatidylinositol N-acetylglucosaminyltransferase activity	IBA	GO_REF
phosphatidylinositol N-acetylglucosaminyltransferase activity	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity

acetylglucosaminyltransferase activity [inference]

phosphatidylinositol N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

phosphatidylinositol N-acetylglucosaminyltransferase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MACRGGAGNGHRASATLSRVSPGSLYTCRTRTHNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVIIVTHAYGNRKGIRYLTSGLKVYYLPLKVMYNQSTATTLFHSLPLLRYIFVRERVTIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSITIVVVSRLVYRKGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTLPAPENIHNIVKTFYTWRNVAERTEKVYDRVSVEAVLPMDKRLDRLISHCGPVTGYIFALLAVFNFLFLIFLRWMTPDSIIDVAIDATGPRGAWTNNYSHSKRGGENNEISETR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
467	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Synthesis of glycosylphosphatidylinositol (GPI)	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080139	multiple congenital anomalies-hypotonia-seizures syndrome 2	Alliance of Genome Resources
DOID:0060284	paroxysmal nocturnal hemoglobinuria	Glyco-Disease Genes Database Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements