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Phospholipid-transporting ATPase ABCA1

Summary

UniProt ID

P41233

Gene Symbol

Abc1
Abca1

Gene ID

11303

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003614

GlyConnect

ATP-binding cassette sub-family A member 1

GlyGen

P41233

PubChem

P41233

Re-Glyco

P41233

Annotation

Keyword

ATP-binding
Cell membrane
Disulfide bond
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport

Gene Ontology (GO)

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GO Term
membrane raft
phagocytic vesicle
endosome
Golgi apparatus
external side of plasma membrane
cell surface
basolateral plasma membrane
endocytic vesicle
perinuclear region of cytoplasm
plasma membrane

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GO Term
phospholipid translocation
lysosome organization
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cholesterol metabolic process
positive regulation of cholesterol efflux
phospholipid transport
cholesterol transport
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle assembly

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GO Term
signaling receptor binding
ATP binding
obsolete phospholipid transporter activity
ATP hydrolysis activity
syntaxin binding
small GTPase binding
apolipoprotein binding
ATPase-coupled transmembrane transporter activity
cholesterol transfer activity
ABC-type transporter activity

Annotation information from UniProt.

Sequence

MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDAQRLLLYSQRDTSIKDMHKVLRMLRQIKHPNSNLKLQDFLVDNETFSGFLQHNLSLPRSTVDSLLQANVGLQKVFLQGYQLHLASLCNGSKLEEIIQLGDAEVSALCGLPRKKLDAAERVLRYNMDILKPVVTKLNSTSHLPTQHLAEATTVLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNNTEEDVDTFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQIWTFMENSQEMDLVRTLLDSRGNDQFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
14	N-linked (GlcNAc...) asparagine			UniProt GlyGen
86				GlyGen
98	N-linked (GlcNAc...) asparagine	30899004	G70101JE G64527OM G41247ZX	GlycoProtDB UniProt GlyGen GlyConnect
151	N-linked (GlcNAc...) asparagine		G41978TW	GlycoProtDB UniProt GlyGen
161	N-linked (GlcNAc...) asparagine		G23763WX	GlycoProtDB UniProt GlyGen
196	N-linked (GlcNAc...) asparagine		G77547TA	UniProt GlyGen
244	N-linked (GlcNAc...) asparagine			UniProt GlyGen
292	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
337	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
349	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen