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Signal transducer and activator of transcription 3

Summary

UniProt ID

P42227

Gene Symbol

Stat3
Aprf

Organism

Mus musculus (house mouse)

External Links

GlyGen: P42227
PubChem: P42227
The O-GlcNAc Database: P42227
RaftProt: P42227
O-GlcNAcAtlas: P42227

Annotation

Keyword

3D-structure
Acetylation
Activator
Acute phase
Alternative splicing
Cytoplasm
DNA-binding
Direct protein sequencing
Nucleus
Phosphoprotein
Reference proteome
SH2 domain
Transcription regulation

Gene Ontology (GO)

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GO Term
sexual reproduction
positive regulation of cell migration
regulation of cell population proliferation
glucose homeostasis
positive regulation of angiogenesis
negative regulation of inflammatory response
regulation of cell cycle
negative regulation of autophagy
response to estradiol
positive regulation of interleukin-1 beta production

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GO Term
RNA polymerase II transcription regulator complex
postsynaptic density
Schaffer collateral - CA1 synapse

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GO Term
chromatin DNA binding
CCR5 chemokine receptor binding
nuclear glucocorticoid receptor binding
identical protein binding
protein homodimerization activity
protein dimerization activity
transcription cis-regulatory region binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity

Annotation information from UniProt.

Sequence

MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	GlyTouCan ID	Source
401	G97993TU	GlyGen
714	G49108TO	GlyGen The O-GlcNAc Database
716	G49108TO	GlyGen
717	G49108TO	GlyGen The O-GlcNAc Database
719	G49108TO	GlyGen The O-GlcNAc Database
721	G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Interleukin-6 signaling	Mus musculus
Interleukin-7 signaling	Mus musculus
Interleukin-9 signaling	Mus musculus
MET activates STAT3	Mus musculus
PKR-mediated signaling	Mus musculus
PTK6 Activates STAT3	Mus musculus
STAT3 nuclear events downstream of ALK signaling	Mus musculus
Signaling by ALK	Mus musculus
Signaling by SCF-KIT	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements