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MIRAGE
Glutamate receptor 1
Summary
- UniProt ID
- P42261
- Gene Symbol
-
- GLUA1
- GLUH1
- GLUR1
- GRIA1
- Gene ID
- [2890]
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Alternative splicing Cell membrane Cell projection Disease variant Disulfide bond Endoplasmic reticulum Endosome Glycoprotein Intellectual disability Ligand-gated ion channel Palmitate Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Signal Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| regulation of receptor recycling | ||
| signal transduction | ||
| chemical synaptic transmission | ||
| synapse assembly | ||
| long-term memory |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| amyloid-beta binding | ||
| amyloid-beta binding | ||
| G-protein alpha-subunit binding | ||
| AMPA glutamate receptor activity | ||
| AMPA glutamate receptor activity |
GO Hierarchy
molecular function
transporter activity [inference]
binding [inference]
Sequence
MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMPLGATGL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 63 |
|
|
||
| 249 |
|
|
||
| 257 |
|
|
||
| 362 |
|
|||
| 363 |
|
|
||
| 401 |
|
|
||
| 406 |
|
|
||
| 849 |
|
G27391WQ
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of AMPA receptors | Homo sapiens |
| COPII-mediated vesicle transport | Homo sapiens |
| Cargo concentration in the ER | Homo sapiens |
| Long-term potentiation | Homo sapiens |
| Synaptic adhesion-like molecules | Homo sapiens |
| Trafficking of AMPA receptors | Homo sapiens |
| Trafficking of GluR2-containing AMPA receptors | Homo sapiens |
| Unblocking of NMDA receptors, glutamate binding and activation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1826 | epilepsy | |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | |
| DOID:0081235 | autosomal recessive intellectual developmental disorder 76 |
