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MIRAGE
Glutamate receptor 3
Summary
- UniProt ID
- P42263
- Gene Symbol
- GRIA3 GLUR3 GLURC GluA3
- Gene ID
- 2892
- Organism
- Homo sapiens (human)
External Links
- PubChem
- P42263
- The Human Metabolome Database
- HMDBP12049
- Re-Glyco
- P42263
Annotation
- Keyword
- Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Intellectual disability Ligand-gated ion channel Palmitate Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Signal Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| glutamate receptor signaling pathway | ||
| synaptic transmission, glutamatergic | ||
| modulation of chemical synaptic transmission | ||
| protein homotetramerization | ||
| protein heterotetramerization |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| endocytic vesicle membrane | ||
| endocytic vesicle membrane |
| GO Term | Evidence Code | Reference |
|---|---|---|
| amyloid-beta binding | ||
| glutamate-gated receptor activity | ||
| glutamate-gated receptor activity | ||
| AMPA glutamate receptor activity | ||
| AMPA glutamate receptor activity |
GO Hierarchy
molecular function
transporter activity [inference]
Sequence
MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of AMPA receptors | Homo sapiens |
| Synaptic adhesion-like molecules | Homo sapiens |
| Trafficking of AMPA receptors | Homo sapiens |
| Trafficking of GluR2-containing AMPA receptors | Homo sapiens |
| Unblocking of NMDA receptors, glutamate binding and activation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060823 | syndromic X-linked intellectual disability 94 |
