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Tyrosine-protein kinase ABL2

Summary

UniProt ID

P42684

Gene Symbol

ABL2
ABLL
ARG

Gene ID

[27]

Organism

Homo sapiens (human)

External Links

GlyGen: P42684
PubChem: P42684
The Human Metabolome Database: HMDBP01329
Re-Glyco: P42684

Annotation

Keyword: 3D-structure ATP-binding Acetylation Alternative splicing Cell adhesion Cytoskeleton Magnesium Manganese Metal-binding Myristate Phosphoprotein Proteomics identification Reference proteome SH2 domain SH3 domain Tyrosine-protein kinase Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
cell adhesion
signal transduction	TAS	PMID
signal transduction	IEA	GO_REF
epidermal growth factor receptor signaling pathway	IBA	GO_REF
phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

macromolecule modification [inference]

protein modification process

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

multicellular organismal process [inference]

behavior [inference]

exploration behavior

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

response to lipid [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

response to oxygen-containing compound [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cell motility

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of autophagy

regulation of cell adhesion

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of establishment or maintenance of cell polarity [inference]

regulation of establishment of cell polarity [inference]

regulation of establishment of T cell polarity [inference]

positive regulation of establishment of T cell polarity

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of cellular component organization [inference]

regulation of endocytosis

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of cell motility

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 5** entries
GO Term	Evidence Code	Reference
cytosol	TAS	Reactome Reactome Reactome
cytosol	IEA	GO_REF
plasma membrane	IBA	GO_REF
actin cytoskeleton	TAS	PMID
actin cytoskeleton	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
magnesium ion binding	IDA	PMID
magnesium ion binding	IEA	GO_REF
phosphotyrosine residue binding	IPI	PMID
phosphotyrosine residue binding	IEA	GO_REF
actin monomer binding	TAS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding [inference]

enzyme binding

phosphoprotein binding [inference]

protein phosphorylated amino acid binding [inference]

phosphotyrosine residue binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

manganese ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites