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Leukemia inhibitory factor receptor

Summary

UniProt ID: P42703
Gene Symbol: Lifr
Gene ID: 16880
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003622

GlyConnect

Leukemia inhibitory factor receptor

GlyGen

P42703

PubChem

P42703

Re-Glyco

P42703

Annotation

Keyword: 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Phosphoprotein Receptor Reference proteome Repeat Secreted Signal Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
positive regulation of cell population proliferation	ISO	GO_REF GO_REF
positive regulation of cell population proliferation	IGI	PMID
positive regulation of cell population proliferation	IBA	GO_REF
positive regulation of cell population proliferation	IEA	GO_REF
negative regulation of muscle cell apoptotic process	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

cytokine-mediated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

cytokine-mediated signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

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GO Term	Evidence Code	Reference
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF
external side of plasma membrane	IBA	GO_REF
signaling receptor complex	ISO	GO_REF
signaling receptor complex	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

extracellular region

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
cytokine receptor activity	ISS	GO_REF
cytokine receptor activity	ISO	GO_REF
cytokine receptor activity	IBA	GO_REF
cytokine receptor activity	IEA	GO_REF GO_REF
leukemia inhibitory factor receptor activity	ISO	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

ciliary neurotrophic factor receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity [inference]

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

immune receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity [inference]

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAAYSWWRQPSWMVDNKRSRMTPNLPWLLSALTLLHLTMHANGLKRGVQDLKCTTNNMRVWDCTWPAPLGVSPGTVKDICIKDRFHSCHPLETTNVKIPALSPGDHEVTINYLNGFQSKFTLNEKDVSLIPETPEILDLSADFFTSSLLLKWNDRGSALPHPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWNWTSDLPLQCATHSVSIRWHIDSPHFSGYKEWSDWSPLKNISWIRNTETNVFPQDKVVLAGSNMTICCMSPTKVLSGQIGNTLRPLIHLYGQTVAIHILNIPVSENSGTNIIFITDDDVYGTVVFAGYPPDVPQKLSCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRIEGLTNETYRLGVQMHPGQEIHNFTLTGRNPLGQAQSAVVINVTERVAPHDPTSLKVKDINSTVVTFSWYLPGNFTKINLLCQIEICKANSKKEVRNATIRGAEDSTYHVAVDKLNPYTAYTFRVRCSSKTFWKWSRWSDEKRHLTTEATPSKGPDTWREWSSDGKNLIVYWKPLPINEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQLSKNDYIISVVARNSAGSSPPSKIASMEIPNDDITVEQAVGLGNRIFLTWRHDPNMTCDYVIKWCNSSRSEPCLLDWRKVPSNSTETVIESDQFQPGVRYNFYLYGCTNQGYQLLRSIIGYVEELAPIVAPNFTVEDTSADSILVKWDDIPVEELRGFLRGYLFYFQKGERDTPKTRSLEPHHSDIKLKNITDISQKTLRIADLQGKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSNALKTLEMNPCTPNNVEVLESRSIVPKIEDTEIISPVAERPGERSEVDPENHVVVSYCPPIIEEEITNPAADEVGGASQVVYIDVQSMYQPQAKAEEEQDVDPVVVAGYKPQMRLPISPAVEDTAAEDEEGKTAGYRPQANVNTWNLVSPDSPRSTDSNNEVVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 17 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
164	N-linked (GlcNAc...) asparagine	17652170	G02815KT	GlycoProtDB UniProt GlyGen
199	N-linked (GlcNAc...) asparagine	17652170		GlycoProtDB UniProt GlyGen
238	N-linked (GlcNAc...) asparagine	17652170		UniProt GlyGen
261	N-linked (GlcNAc...) asparagine	17652170		GlycoProtDB UniProt GlyGen
385	N-linked (GlcNAc...) asparagine	16944957 17330941 17652170 19349973	G27126ED	GlycoProtDB UniProt GlyGen
402	N-linked (GlcNAc...) asparagine	16944957 17652170 30899004	G23863VK G59924QI G50045TK G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
421	N-linked (GlcNAc...) asparagine	17652170	G80920RR	GlycoProtDB UniProt GlyGen
440	N-linked (GlcNAc...) asparagine	17652170		GlycoProtDB UniProt GlyGen
453	N-linked (GlcNAc...) asparagine	17652170		GlycoProtDB UniProt GlyGen
476	N-linked (GlcNAc...) asparagine	30899004	G62765YT G05724UK	UniProt GlyGen GlyConnect