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Excitatory amino acid transporter 2

Summary

UniProt ID: P43006
Gene Symbol: Eaat2 Glt1 RP23-163L4.1-001 RP23-163L4.1-002 RP23-163L4.1-003 RP23-163L4.1-004 Slc1a2
Gene ID: 20511
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003624

GlyConnect

Excitatory amino acid transporter 2

GlyGen

P43006

PubChem

P43006

The O-GlcNAc Database

P43006

O-GlcNAcAtlas

P43006

Re-Glyco

P43006

Annotation

Keyword: Alternative splicing Amino-acid transport Cell membrane Chloride Direct protein sequencing Glycoprotein Metal-binding Palmitate Phosphoprotein Potassium Reference proteome Sodium Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	Reference
glutathione biosynthetic process	IDA	PMID
nervous system development	IMP	PMID
visual behavior	IMP	PMID
response to xenobiotic stimulus	IMP	PMID PMID
response to light stimulus	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

modified amino acid metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

biosynthetic process [inference]

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

multicellular organismal process [inference]

behavior [inference]

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

telencephalon development

system development [inference]

nervous system development

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress [inference]

response to wounding

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus

visual behavior

response to chemical [inference]

response to acid chemical [inference]

response to amino acid

response to xenobiotic stimulus

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

response to nitrogen compound [inference]

response to alkaloid [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to oxygen-containing compound [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

neurotransmitter transport [inference]

neurotransmitter uptake [inference]

neurotransmitter reuptake

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

nitrogen compound transport [inference]

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

import into cell [inference]

neurotransmitter uptake [inference]

neurotransmitter reuptake

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

establishment of localization in cell [inference]

neurotransmitter reuptake

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF GO_REF
plasma membrane	EXP	PMID
plasma membrane	TAS	PMID
plasma membrane	IC	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

synaptic membrane [inference]

presynaptic membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

glutamatergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron spine [inference]

dendritic spine

glial cell projection [inference]

astrocyte projection

dendritic shaft

organelle [inference]

membrane-bounded organelle [inference]

vesicle

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
L-glutamate transmembrane transporter activity	ISO	GO_REF
L-glutamate transmembrane transporter activity	IDA	PMID
L-glutamate transmembrane transporter activity	IMP	PMID
L-glutamate transmembrane transporter activity	IBA	GO_REF
L-glutamate transmembrane transporter activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

monoatomic anion transmembrane transporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

cysteine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MASTEGANNMPKQVEVRMHDSHLSSDEPKHRNLGMRMCDKLGKNLLLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEETKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRMQEDIEMTKTQSIYDDKNHRESNSNQCVYAAHNSVVIDECKVTLAANGKSADCSVEEEPWKREK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
201		33300544 34678516 40021952 40885482	G49108TO	The O-GlcNAc Database
205	N-linked (GlcNAc...) asparagine	30899004	G70894RY G27947YN G10773YW G70101JE G64527OM G55383ZG G05724UK G39188ZX G06110VR G66538GV G74724QE G14669DU G31685JQ	GlycoProtDB UniProt GlyGen GlyConnect
206		33300544 34678516 40021952 40885482	G49108TO	The O-GlcNAc Database
215	N-linked (GlcNAc...) asparagine	30899004	G15127JD G48584BU G64527OM G39188ZX G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
518			G49108TO	GlyGen
551			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Astrocytic Glutamate-Glutamine Uptake And Metabolism	Mus musculus
Glutamate Neurotransmitter Release Cycle	Mus musculus
SLC-mediated transport of amino acids	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

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Acknowledgements