Pro-neuregulin-1, membrane-bound isoform
| GO Term | Evidence Code | Reference |
|---|---|---|
| MAPK cascade | ||
| cell morphogenesis | ||
| neuron migration |
|
|
| cardiac conduction system development | ||
| ventricular trabecula myocardium morphogenesis |
| GO Term | Evidence Code | Reference |
|---|---|---|
| obsolete extracellular space |
|
|
| nucleoplasm |
|
|
| cytoplasm | ||
| plasma membrane | ||
| plasma membrane |
| GO Term | Evidence Code | Reference |
|---|---|---|
| transcription coregulator activity | ||
| signaling receptor binding | ||
| signaling receptor binding | ||
| ErbB-2 class receptor binding | ||
| integrin binding |
| Pathway Name | Organism |
|---|---|
| Downregulation of ERBB2 signaling | Rattus norvegicus |
| Downregulation of ERBB2:ERBB3 signaling | Rattus norvegicus |
| ERBB2 Activates PTK6 Signaling | Rattus norvegicus |
| ERBB2 Regulates Cell Motility | Rattus norvegicus |
| GRB2 events in ERBB2 signaling | Rattus norvegicus |
| GRB7 events in ERBB2 signaling | Rattus norvegicus |
| PI3K events in ERBB2 signaling | Rattus norvegicus |
| PI3K events in ERBB4 signaling | Rattus norvegicus |
| PI3K/AKT Signaling | Rattus norvegicus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Rattus norvegicus |
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10652 | Alzheimer's disease | |
| DOID:11446 | sciatic neuropathy |
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Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
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Last updated: April 6, 2026