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Vesicle-fusing ATPase

Summary

UniProt ID

P46460

Gene Symbol

Nsf
Skd2

Gene ID

18195

Organism

Mus musculus (house mouse)

External Links

GlyGen: P46460
PubChem: P46460
RaftProt: P46460
Re-Glyco: P46460

Annotation

Keyword: ATP-binding Acetylation Cytoplasm Direct protein sequencing Hydrolase Magnesium Metal-binding Phosphoprotein Protein transport Reference proteome Repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
positive regulation of receptor recycling	ISO	GO_REF
positive regulation of receptor recycling	IEA	GO_REF
regulation of receptor internalization	ISO	GO_REF
positive regulation of receptor internalization	ISO	GO_REF
potassium ion transport	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport

Golgi vesicle transport [inference]

intra-Golgi vesicle-mediated transport

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly

SNARE complex disassembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein-containing complex organization [inference]

protein-containing complex disassembly

SNARE complex disassembly

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

protein transport [inference]

vesicle-mediated transport

Golgi vesicle transport [inference]

intra-Golgi vesicle-mediated transport

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

secretion [inference]

surfactant secretion

intracellular transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

positive regulation of postsynaptic membrane organization [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

positive regulation of postsynaptic membrane organization [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

positive regulation of postsynaptic membrane organization [inference]

positive regulation of AMPA glutamate receptor clustering

regulation of postsynaptic membrane organization [inference]

positive regulation of postsynaptic membrane organization [inference]

positive regulation of AMPA glutamate receptor clustering

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of AMPA glutamate receptor clustering

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis

positive regulation of receptor internalization

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
Golgi membrane	ISO	GO_REF
Golgi apparatus	ISO	GO_REF
Golgi stack	ISO	GO_REF
Golgi stack	IBA	GO_REF
cytosol	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

bounding membrane of organelle [inference]

Golgi membrane

cell junction [inference]

synapse [inference]

GABA-ergic synapse

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

actin-based cell projection [inference]

filopodium [inference]

dendritic filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

exocytic vesicle [inference]

synaptic vesicle

membraneless organelle [inference]

intracellular membraneless organelle [inference]

postsynaptic specialization, intracellular component

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

exocytic vesicle [inference]

synaptic vesicle

intracellular membraneless organelle [inference]

postsynaptic specialization, intracellular component

postsynaptic specialization [inference]

postsynaptic density

neuron projection terminus [inference]

axon terminus

dendritic spine neck

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
SNARE binding	ISS	GO_REF
calcium ion binding	ISO	GO_REF
ATP binding	IEA	GO_REF
ATP hydrolysis activity	ISO	GO_REF
ATP hydrolysis activity	IMP	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

SNARE binding

syntaxin binding

syntaxin-1 binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

dopamine receptor binding [inference]

D1 dopamine receptor binding

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein serine/threonine kinase binding

GTPase binding [inference]

small GTPase binding

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATP-dependent protein disaggregase activity

protein-containing complex destabilizing activity [inference]

ATP-dependent protein disaggregase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAGRTMQAARCPTDELSLSNCAVVNEKDFQSGQHVMVRTSPNHKYIFTLRTHPSVVPGCIAFSLPQRKWAGLSIGQDIEVALYSFDKAKQCIGTMTIEIDFLQKKNIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNDKLFGLLVKDIEAMDPSILKGEPASGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALMREEGASPLDFD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
190			G80920RR	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
COPI-dependent Golgi-to-ER retrograde traffic	Mus musculus
COPI-mediated anterograde transport	Mus musculus
COPII-mediated vesicle transport	Mus musculus
Intra-Golgi traffic	Mus musculus
Retrograde transport at the Trans-Golgi-Network	Mus musculus
Trafficking of GluR2-containing AMPA receptors	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements