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RAC-alpha serine/threonine-protein kinase
Summary
- UniProt ID
- P47196
- Gene Symbol
-
- Akt1
- Gene ID
- 24185
- Organism
- Rattus norvegicus (Norway rat)
External Links
- GlyGen
- P47196
- PubChem
- P47196
- The Human Metabolome Database
- HMDBP13421
- The O-GlcNAc Database
- P47196
- Re-Glyco
- P47196
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Apoptosis
- Cell membrane
- Cytoplasm
- Developmental protein
- Disulfide bond
- Glucose metabolism
- Glycogen biosynthesis
- Glycogen metabolism
- Glycoprotein
- Isopeptide bond
- Mitochondrion
- Neurogenesis
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Sugar transport
- Translation regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| mitochondrion |
| plasma membrane |
| cell-cell junction |
| membrane |
| dendrite |
| vesicle |
| protein-containing complex |
| nucleoplasm |
Sequence
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 126 | O-linked (GlcNAc) serine; alternate |
|
||
| 129 | O-linked (GlcNAc) serine; alternate |
|
||
| 305 | O-linked (GlcNAc) threonine |
|
||
| 312 | O-linked (GlcNAc) threonine |
|
||
| 473 | O-linked (GlcNAc) serine; alternate |
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Negative regulation of NOTCH4 signaling | Rattus norvegicus |
| Negative regulation of the PI3K/AKT network | Rattus norvegicus |
| PI3K/AKT Signaling | Rattus norvegicus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Rattus norvegicus |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | Rattus norvegicus |
| RAB GEFs exchange GTP for GDP on RABs | Rattus norvegicus |
| Regulation of PTEN stability and activity | Rattus norvegicus |
| Regulation of TP53 Activity through Acetylation | Rattus norvegicus |
| Regulation of TP53 Activity through Association with Co-factors | Rattus norvegicus |
| Regulation of TP53 Degradation | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110861 | autosomal recessive polycystic kidney disease | |
| DOID:10763 | hypertension | |
| DOID:1875 | impotence | |
| DOID:5844 | myocardial infarction | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9976 | heroin dependence |
