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MIRAGE
Angiotensin-converting enzyme
Summary
- UniProt ID
- P47820
- Gene Symbol
-
- Ace
- Dcp1
- Gene ID
- 24310
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Alternative promoter usage
- Calmodulin-binding
- Carboxypeptidase
- Cell membrane
- Cytoplasm
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| cytoplasm |
| lysosome |
| plasma membrane |
| vesicle |
| endosome |
| external side of plasma membrane |
| basal plasma membrane |
| brush border membrane |
| extracellular exosome |
Sequence
MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPALDPGLQPGNFSADEAGAQLFADSYNSSAEVVMFQSTAASWAHDTNITEENARLQEEAALINQEFAEVWGKKAKELYESIWQNFTDQKLRRIIGSVQTLGPANLPLTQRLQYNSLLSNMSRIYSTGKVCFPNKTATCWSLDPELTNILASSRNYAKVLFAWEGWHDAVGIPLRPLYQDFTALSNEAYRQDGFSDTGAYWRSWYESPSFEESLEHLYHQVEPLYLNLHAFVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEEFFTSLGLSPMPPEFWAESMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVANDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVARNETHFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSTKAGAKLQQVLQAGCSRPWQEVLKDLVGSDALDASALMEYFQPVSQWLQEQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKNKEVSNHTLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVCYTNGTCLSLEPDLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSDAGDSWRSSYESDDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRAAGHTGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEWLVTENRRHGETLGWPEYTWTPNTARAEGSLPESSRVNFLGMYLEPQQARVGQWVLLFLGVALLVATVGLAHRLYNIHNHHSLRRPHRGPQFGSEVELRHS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 44 | N-linked (GlcNAc...) asparagine |
|
||
| 60 | N-linked (GlcNAc...) asparagine |
|
||
| 80 | N-linked (GlcNAc...) asparagine |
|
||
| 117 | N-linked (GlcNAc...) asparagine |
|
||
| 152 | N-linked (GlcNAc...) asparagine |
|
||
| 166 | N-linked (GlcNAc...) asparagine |
|
||
| 324 | N-linked (GlcNAc...) asparagine |
|
||
| 515 | N-linked (GlcNAc...) asparagine |
|
||
| 683 | N-linked (GlcNAc...) asparagine |
|
||
| 701 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Metabolism of Angiotensinogen to Angiotensins | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050851 | glomerulosclerosis | |
| DOID:0050855 | renal fibrosis | |
| DOID:0060071 | pre-malignant neoplasm | |
| DOID:0110861 | autosomal recessive polycystic kidney disease | |
| DOID:0111128 | focal segmental glomerulosclerosis 1 | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10763 | hypertension | |
| DOID:11476 | osteoporosis | |
| DOID:1184 | nephrotic syndrome | |
| DOID:12986 | leukostasis |
