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Alpha-L-iduronidase

Summary

UniProt ID

P48441

Gene Symbol

Idua

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003643

GlyConnect

Alpha-L-iduronidase

GlyGen

P48441

PubChem

P48441

Re-Glyco

P48441

Annotation

Keyword: Disulfide bond Glycoprotein Glycosidase Lysosome Reference proteome Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	Reference
cell morphogenesis	IMP	PMID
carbohydrate metabolic process	IEA	GO_REF
glycosaminoglycan catabolic process	ISO	GO_REF
glycosaminoglycan catabolic process	IDA	PMID
glycosaminoglycan catabolic process	IMP	PMID PMID PMID PMID PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan catabolic process

heparin proteoglycan metabolic process [inference]

heparin proteoglycan catabolic process

dermatan sulfate proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan catabolic process

heparin proteoglycan metabolic process [inference]

heparin proteoglycan catabolic process

dermatan sulfate proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan catabolic process

heparin proteoglycan metabolic process [inference]

heparin proteoglycan catabolic process

dermatan sulfate proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

locomotory behavior

adult locomotory behavior

adult walking behavior

walking behavior [inference]

adult walking behavior

visual behavior [inference]

visual learning

adult behavior [inference]

adult locomotory behavior

adult walking behavior

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

animal organ morphogenesis [inference]

skeletal system morphogenesis

appendage morphogenesis [inference]

limb morphogenesis

anatomical structure development [inference]

animal organ development [inference]

bone development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

chemical homeostasis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of developmental process [inference]

negative regulation of cartilage development

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of cartilage development

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

negative regulation of cartilage development

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of collagen catabolic process

regulation of collagen catabolic process [inference]

positive regulation of collagen catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen catabolic process

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption [inference]

positive regulation of bone resorption

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

negative regulation of cartilage development

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GO Term	Evidence Code	Reference
obsolete extracellular space
lysosome	ISS	GO_REF
lysosome	IMP	PMID
lysosome	IEA	GO_REF
lysosomal lumen	IMP	PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

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GO Term	Evidence Code	Reference
L-iduronidase activity	ISS	GO_REF
L-iduronidase activity	ISO	GO_REF GO_REF
L-iduronidase activity	IDA	PMID PMID PMID
L-iduronidase activity	IMP	PMID PMID PMID PMID
L-iduronidase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

L-iduronidase activity

binding [inference]

protein binding [inference]

signaling receptor binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLTFFAAFLAAPLALAESPYLVRVDAARPLRPLLPFWRSTGFCPPLPHDQADQYDLSWDQQLNLAYIGAVPHSGIEQVRIHWLLDLITARKSPGQGLMYNFTHLDAFLDLLMENQLLPGFELMGSPSGYFTDFDDKQQVFEWKDLVSLLARRYIGRYGLTHVSKWNFETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLKLGGPGDSFHPLPRSPMCWSLLGHCANGTNFFTGEVGVRLDYISLHKKGAGSSIAILEQEMAVVEQVQQLFPEFKDTPIYNDEADPLVGWSLPQPWRADVTYAALVVKVIAQHQNLLFANSSSSMRYVLLSNDNAFLSYHPYPFSQRTLTARFQVNNTHPPHVQLLRKPVLTVMGLMALLDGEQLWAEVSKAGAVLDSNHTVGVLASTHHPEGSAAAWSTTVLIYTSDDTHAHPNHSIPVTLRLRGVPPGLDLVYIVLYLDNQLSSPYSAWQHMGQPVFPSAEQFRRMRMVEDPVAEAPRPFPARGRLTLHRKLPVPSLLLVHVCTRPLKPPGQVSRLRALPLTHGQLILVWSDERVGSKCLWTYEIQFSQKGEEYAPINRRPSTFNLFVFSPDTAVVSGSYRVRALDYWARPGPFSDPVTYLDVPAS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
100	N-linked (GlcNAc...) asparagine			UniProt GlyGen
180	N-linked (GlcNAc...) asparagine			UniProt GlyGen
233	N-linked (GlcNAc...) asparagine		G84349RE	UniProt GlyGen
326	N-linked (GlcNAc...) asparagine	30899004	G39188ZX	GlycoProtDB UniProt GlyGen GlyConnect
362	N-linked (GlcNAc...) asparagine	30899004	G70101JE G80920RR G64527OM G05724UK G39188ZX G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
405	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
441	N-linked (GlcNAc...) asparagine			UniProt GlyGen