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Natural resistance-associated macrophage protein 2

Summary

UniProt ID: P49282
Gene Symbol: Slc11a2 Dct1 Dmt1 Nramp2
Gene ID: 18174
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003650
PubChem: P49282
Re-Glyco: P49282

Annotation

Keyword: Alternative splicing Cell membrane Disease variant Endosome Glycoprotein Golgi apparatus Iron transport Lysosome Mitochondrion outer membrane Phosphoprotein Reference proteome Symport Transmembrane helix Ubl conjugation

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
transition metal ion transport	ISO	GO_REF
porphyrin-containing compound metabolic process	IMP	PMID
porphyrin-containing compound biosynthetic process	IMP	PMID
heme biosynthetic process	IMP	PMID
cobalt ion transport	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

pigment metabolic process [inference]

heme metabolic process [inference]

heme biosynthetic process

pigment biosynthetic process [inference]

heme biosynthetic process

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

intracellular manganese ion homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

intracellular manganese ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

intracellular manganese ion homeostasis

manganese ion homeostasis [inference]

intracellular manganese ion homeostasis

multicellular organismal-level iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

intracellular manganese ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

manganese ion homeostasis [inference]

intracellular manganese ion homeostasis

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

response to metal ion [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport

cobalt ion transport

copper ion transport

copper ion transmembrane transport [inference]

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

iron ion transport

cadmium ion transport [inference]

cadmium ion transmembrane transport

lead ion transport

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

establishment of localization in cell [inference]

iron import into cell

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GO Term	Evidence Code	Reference
nucleus	ISO	GO_REF
nucleus	IEA	GO_REF
cytoplasm	ISO	GO_REF
cytoplasm	IEA	GO_REF
mitochondrion	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

paraferritin complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

organelle outer membrane [inference]

mitochondrial outer membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

extracellular vesicle

intracellular membrane-bounded organelle [inference]

vacuole

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

cluster of actin-based cell projections [inference]

brush border

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GO Term	Evidence Code	Reference
copper ion transmembrane transporter activity	ISO	GO_REF GO_REF
copper ion transmembrane transporter activity	IEA	GO_REF
iron ion transmembrane transporter activity	ISO	GO_REF GO_REF
iron ion transmembrane transporter activity	IDA	PMID
iron ion transmembrane transporter activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

solute:proton symporter activity

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity

metal ion transmembrane transporter activity [inference]

lead ion transmembrane transporter activity

transition metal ion transmembrane transporter activity

copper ion transmembrane transporter activity

iron ion transmembrane transporter activity

ferrous iron transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

protein-containing complex binding [inference]

retromer complex binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVLDPKEKMPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYITVKPSQSQVLRGMFVPSCPGCRTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFEKTNKQVVEVCKNNSSPHADLFPSDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLIVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLTFVFYLGWQCLIALGLSFLDCGRSYRLGLTAQPELYLLNTVDADSVVSR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites