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Cartilage oligomeric matrix protein

Summary

UniProt ID: P49747
Gene Symbol: COMP
Gene ID: 1311
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011711

GlyConnect

Cartilage oligomeric matrix protein

GlyGen

P49747

PubChem

P49747

The Human Metabolome Database

HMDBP02410

Re-Glyco

P49747

Annotation

Keyword: 3D-structure Alternative splicing Apoptosis Calcium Cell adhesion Direct protein sequencing Disease variant Disulfide bond Dwarfism EGF-like domain Extracellular matrix Glycoprotein Heparin-binding Proteomics identification Reference proteome Repeat Signal

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
skeletal system development	TAS	PMID
chondrocyte development
growth plate cartilage development
apoptotic process
response to unfolded protein

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation [inference]

chondrocyte proliferation

cellular developmental process [inference]

cell development [inference]

chondrocyte development

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

cellular senescence

export from cell [inference]

secretion by cell [inference]

protein secretion

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

vascular associated smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

nervous system process [inference]

neuromuscular process [inference]

musculoskeletal movement

multicellular organism growth

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

multicellular organismal movement [inference]

musculoskeletal movement

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis

anatomical structure development [inference]

cell development [inference]

chondrocyte development

muscle cell development [inference]

vascular associated smooth muscle cell development

system development [inference]

skeletal system development

animal gross anatomical part developmental process [inference]

skeletal system development

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

connective tissue development [inference]

animal organ development [inference]

skin development

cartilage development [inference]

cartilage development involved in endochondral bone morphogenesis [inference]

growth plate cartilage development

appendage development [inference]

limb development

cellular developmental process [inference]

cell development [inference]

chondrocyte development

muscle cell development [inference]

vascular associated smooth muscle cell development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein secretion

protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

protein transport [inference]

protein secretion

secretion [inference]

secretion by cell [inference]

protein secretion

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of hemostasis

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of hemostasis [inference]

negative regulation of hemostasis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

negative regulation of hemostasis

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome Reactome
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF GO_REF
extracellular region	HDA	PMID PMID
obsolete extracellular space

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	Reference
protease binding	IPI	PMID
protease binding	IEA	GO_REF
integrin binding	IEA	GO_REF
extracellular matrix structural constituent	RCA	PMID
extracellular matrix structural constituent	TAS	PMID

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

cytokine binding [inference]

BMP binding

proteoglycan binding

heparan sulfate proteoglycan binding

cell adhesion molecule binding [inference]

integrin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVPDTACVLLLTLAALGASGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGARCGPCPAGFTGNGSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSRSCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDADRDGVGDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYETHQLRQA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
121	N-linked (GlcNAc...) asparagine	23090970 29671580 29741879 37074911	G20706XG G02030ZB G72667IM G15664MX G84452RH G37509XX G10488MI G91636VS G23863VK G83555HU G90659AW	GlycoProtDB UniProt GlyGen GlyConnect
742	N-linked (GlcNAc...) asparagine	19276170 23090970 29671580 29741879 37074911	G49642SA G15664MX G83460ZZ G70101JE G80920RR G62765YT G31852PQ G41247ZX	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
ECM proteoglycans	Homo sapiens
Integrin cell surface interactions	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080047	pseudoachondroplasia	Alliance of Genome Resources
DOID:0070303	multiple epiphyseal dysplasia 1	Alliance of Genome Resources
DOID:0070467	carpal tunnel syndrome 2	Alliance of Genome Resources
DOID:2256	osteochondrodysplasia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements