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Aldehyde dehydrogenase 1A1

Summary

UniProt ID

P51647

Gene Symbol

Aldh
Aldh1a1

Gene ID

24188

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen

P51647

PubChem

P51647

SwissLipids

SLP:000000800

Re-Glyco

P51647

Annotation

Keyword: Acetylation Cell projection Cytoplasm Direct protein sequencing Lipid metabolism NAD Oxidoreductase Phosphoprotein Reference proteome

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
retinoid metabolic process	IDA	PMID
kidney development	IEP	PMID
liver development	IEP	PMID
optic cup morphogenesis involved in camera-type eye development	ISO	GO_REF
retinoic acid biosynthetic process	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process

catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

fructosamine catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

amino acid biosynthetic process [inference]

GABA biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

hormone metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process

hexose catabolic process [inference]

fructose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process

hexose catabolic process [inference]

fructose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

olefinic compound metabolic process [inference]

retinol metabolic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

fructosamine metabolic process [inference]

fructosamine catabolic process

amino sugar catabolic process [inference]

fructosamine catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

fructosamine catabolic process

cellular detoxification [inference]

cellular detoxification of aldehyde

reproductive process [inference]

multicellular organismal reproductive process [inference]

ovulation cycle [inference]

estrous cycle

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of lens transparency

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

embryonic eye morphogenesis

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium [inference]

optic cup morphogenesis involved in camera-type eye development

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

optic cup morphogenesis involved in camera-type eye development

anatomical structure development [inference]

tube development [inference]

digestive tract development [inference]

midgut development

animal organ development [inference]

kidney development

gland development [inference]

liver development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of lens transparency

rhythmic process [inference]

ovulation cycle [inference]

estrous cycle

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to chemical [inference]

response to xenobiotic stimulus

response to lipid [inference]

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde

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GO Term	Evidence Code	Reference
cytosol	ISS	GO_REF
cytosol	ISO	GO_REF
cytosol	IBA	GO_REF
cytosol	IEA	GO_REF
axon	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

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GO Term	Evidence Code	Reference
retinal dehydrogenase (NAD+) activity	IDA	PMID PMID
retinal dehydrogenase (NAD+) activity	IEA	GO_REF GO_REF
3-chloroallyl aldehyde dehydrogenase activity	ISO	GO_REF
3-chloroallyl aldehyde dehydrogenase activity	TAS	PMID
aldehyde dehydrogenase (NAD+) activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

3-chloroallyl aldehyde dehydrogenase activity

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSSPAQPAVPAPLANLKIQHTKIFINNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWADKIHGQTIPSDGDIFTFTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTALHMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVLGNPLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAGVVWVNCYMILSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites