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Ephrin type-B receptor 4

Summary

UniProt ID: P54761
Gene Symbol: Ephb4 Htk Mdk2 Myk1
Gene ID: 13846
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003686
GlyGen: P54761
PubChem: P54761
Re-Glyco: P54761

Annotation

Keyword: ATP-binding Angiogenesis Cell membrane Developmental protein Disulfide bond Glycoprotein Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
angiogenesis	ISO	GO_REF
angiogenesis	IMP	PMID
angiogenesis	IBA	GO_REF
angiogenesis	IEA	GO_REF GO_REF
cell migration involved in sprouting angiogenesis	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

cell motility [inference]

cell migration [inference]

endothelial cell migration [inference]

blood vessel endothelial cell migration [inference]

cell migration involved in sprouting angiogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

venous blood vessel morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of T cell costimulation [inference]

positive regulation of T cell costimulation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of developmental process [inference]

positive regulation of artery morphogenesis [inference]

positive regulation of aorta morphogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of artery morphogenesis [inference]

regulation of aorta morphogenesis [inference]

positive regulation of aorta morphogenesis

positive regulation of artery morphogenesis [inference]

positive regulation of aorta morphogenesis

positive regulation of developmental process [inference]

positive regulation of artery morphogenesis [inference]

positive regulation of aorta morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of T cell costimulation [inference]

positive regulation of T cell costimulation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of T cell costimulation [inference]

positive regulation of T cell costimulation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

regulation of T cell costimulation [inference]

positive regulation of T cell costimulation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell costimulation

Displaying **all 5** entries
GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF GO_REF
signaling receptor complex	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
transmembrane receptor protein tyrosine kinase activity	ISS	GO_REF
transmembrane receptor protein tyrosine kinase activity	ISO	GO_REF
transmembrane receptor protein tyrosine kinase activity	IBA	GO_REF
transmembrane receptor protein tyrosine kinase activity	IEA	GO_REF GO_REF
ephrin receptor activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MELRALLCWASLATALEETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSWLITNLTYFPETVPRELVVPVAGSCVANAVPTANPSPSLYCREDGQWAEQQVTGCSCAPGYEAAESNKVCRACGQGTFKPQIGDESCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPCTTPPSAPRSVVHHLNGSTLRLEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDMTFDPGPRDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFEPVNVTTDREVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLALIAGTAVVGVVLVLVVVIIAVLCLRKQSNGREVEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFEVVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGAPGGTGGPAQQF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
203	N-linked (GlcNAc...) asparagine		G47377GD	UniProt GlyGen
335	N-linked (GlcNAc...) asparagine	19349973 19656770	G14972EH	GlycoProtDB UniProt GlyGen
426	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
EPH-Ephrin signaling	Mus musculus
EPH-ephrin mediated repulsion of cells	Mus musculus
EPHB-mediated forward signaling	Mus musculus
Ephrin signaling	Mus musculus