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MIRAGE

Tyrosinase

Summary

UniProt ID: P55033
Gene Symbol: TYR
Gene ID: 751100
Organism: Felis catus (domestic cat)

External Links

Re-Glyco: P55033

Annotation

Keyword: Copper Glycoprotein Melanin biosynthesis Metal-binding Monooxygenase Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	Reference
melanin biosynthetic process	IBA	GO_REF
melanin biosynthetic process	IEA	GO_REF GO_REF
pigmentation	IBA	GO_REF
pigmentation	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

pigment metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

pigment biosynthetic process [inference]

melanin biosynthetic process

pigmentation

Displaying **all 5** entries
GO Term	Evidence Code	Reference
melanosome membrane	ISS	GO_REF
melanosome membrane	IEA	GO_REF
melanosome	ISS	GO_REF
melanosome	IBA	GO_REF
melanosome	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

pigment granule membrane [inference]

melanosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

Displaying **all 5** entries
GO Term	Evidence Code	Reference
tyrosinase activity	ISS	GO_REF
tyrosinase activity	IBA	GO_REF
tyrosinase activity	IEA	GO_REF GO_REF GO_REF
identical protein binding	IEA	GO_REF
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

tyrosinase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

tyrosinase activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLLAALCCLLWSFRTSAGHFPRACASSKSLMEKECCPAWTGDSSPCGQLSGRGACQDITLSKAPLGPQYPFTGMDDREAWPSVFYNRTCQCFGNFMGFNCGNCKFGFWGPNCTEKRLLVRRNIFDLSVPEKNKFLAYLTLAKHTISPDYVIPIGTYGQMNNGSTPMFNDINVYDLFVWMHYYVSRDTLLGGSEIWKDIDFAHEAPGFLPWHRLFLLLWEQEIQKLTGDENFTIPYWDWRDAKSCDICTDEYMGGHNPANPNLLSPASFFSSWQIICTRLEEYNSRQALCDGTPRGPLLRNPGHDKARTPRLPSSADVEFCLSLTQYESDSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHHPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSRDLGYDYSNLQDSERDIFQDYIKPFLEQASRIWPWLIGAAVVGSVLTAVLGRLTSLLCRRKRKQLREERQPLLMEKEDYHSLLYQTHV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
86	N-linked (GlcNAc...) asparagine			UniProt
111	N-linked (GlcNAc...) asparagine			UniProt
161	N-linked (GlcNAc...) asparagine			UniProt
230	N-linked (GlcNAc...) asparagine			UniProt
336	N-linked (GlcNAc...) asparagine			UniProt
370	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026