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Guanylyl cyclase C

Summary

UniProt ID: P55204
Gene Symbol: GUC2C GUCY2C
Gene ID: 397193
Organism: Sus scrofa (pig)

External Links

PubChem: P55204
Re-Glyco: P55204

Annotation

Keyword: Cell membrane Endoplasmic reticulum GTP-binding Glycoprotein Lyase Receptor Reference proteome Signal Transmembrane helix cGMP biosynthesis

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
cGMP biosynthetic process	IBA	GO_REF
receptor guanylyl cyclase signaling pathway	IBA	GO_REF
intracellular signal transduction	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

receptor guanylyl cyclase signaling pathway

intracellular signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide metabolic process [inference]

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide metabolic process [inference]

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide metabolic process [inference]

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide metabolic process [inference]

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cyclic nucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

cyclic purine nucleotide metabolic process [inference]

cGMP metabolic process [inference]

cGMP biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

cGMP metabolic process [inference]

cGMP biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process [inference]

cGMP biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

receptor guanylyl cyclase signaling pathway

intracellular signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	ISS	GO_REF
endoplasmic reticulum membrane	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

1

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GO Term	Evidence Code	Reference
peptide receptor activity	IBA	GO_REF
guanylate cyclase activity	ISS	GO_REF
guanylate cyclase activity	IBA	GO_REF
guanylate cyclase activity	IEA	GO_REF GO_REF GO_REF
protein kinase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

cyclase activity [inference]

guanylate cyclase activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

lyase activity [inference]

phosphorus-oxygen lyase activity [inference]

guanylate cyclase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKTPLLALALWSLLLQLGLTFWPSSVSQNCHNGSYEISVLMMNNSAFPESLDNLKAVVNEGVNIVRQRLLEAGLTVTVNATFVYSEGVIYKSSDCRSSTCEGLDLLRTISSEKRMGCVLLGPSCTYSTFQMYLDTDLNYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVDFWKVNNFPFKPFSWNTAYVFKNSTESEDCFWYLNALEAGVSYFSQKLSFKEMLRGNEEFQNILMDQNRKSNVIIMCGAPETVHTLKGGRAVAEDTVIILVDLFNDHYFMDNVTAPDYMKNVLVLTLPPENSVSNSSFSKDLSLVKNDFTLAYMNGVLLFGHMLKIFLEKREDVTTSKFAHAFRNITFEGHMGPVTLDNCGDIDNTMFLLYTSVDTSKYKVLLTYDTRKNYTNPVDKSPTFIWKNHKLPNDIPGRGPQILMIAVFTLTGTIVLLLLIALLVLRKYKREYALRQKKWSHIPPENIFPLESNETNHVSLKIDDDRRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDSMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILAPKKDLWTAPEHLRRASVSQKGDVYSYGIIAQEIILRRETFYTLSCRDQKEKIFRVENSNGVKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIENTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHILDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALDILSFMGTFELEHLPGLPIWIRIGIHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGTETTYWLTGVKDQEYNLPTPPTAENQQRLQAEFVDMIASSLQKRQASGIKNRKPTRVASYKKGTLEYLQLNTTDNESTHF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	Source
32	N-linked (GlcNAc...) asparagine	UniProt
43	N-linked (GlcNAc...) asparagine	UniProt
79	N-linked (GlcNAc...) asparagine	UniProt
195	N-linked (GlcNAc...) asparagine	UniProt
284	N-linked (GlcNAc...) asparagine	UniProt
307	N-linked (GlcNAc...) asparagine	UniProt
402	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Digestion	Sus scrofa

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements