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Desmocollin-1

Summary

UniProt ID: P55849
Gene Symbol: Dsc1
Gene ID: 13505
Organism: Mus musculus (house mouse)

External Links

GlyGen: P55849
Re-Glyco: P55849

Annotation

Keyword: Alternative splicing Calcium Cell adhesion Cell junction Cell membrane Cleavage on pair of basic residues Glycoprotein Phosphoprotein Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
desmosome maintenance	IMP	PMID
homophilic cell-cell adhesion	IEA	GO_REF
hair follicle morphogenesis	IMP	PMID
negative regulation of epithelial cell proliferation	IMP	PMID
establishment of skin barrier	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

homophilic cell-cell adhesion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

desmosome maintenance

cell-cell junction organization [inference]

desmosome organization [inference]

desmosome maintenance

cell-cell junction maintenance [inference]

desmosome maintenance

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

desmosome maintenance

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

hair follicle morphogenesis

anatomical structure development [inference]

tissue development [inference]

epidermis development [inference]

skin epidermis development [inference]

establishment of skin barrier

epithelium development [inference]

skin epidermis development [inference]

establishment of skin barrier

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	IEA	GO_REF GO_REF
desmosome	IDA	PMID PMID
desmosome	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

Displaying **all 2** entries
GO Term	Evidence Code	Reference
calcium ion binding	IBA	GO_REF
calcium ion binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAVACAAPGSTFSKQLLFFLLVLVLFCDACQKVSLHVPSHLKAETPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLGPFPQHIQQIQSDAAQNYTIFYSISGPGVDKEPYNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTADGYAPDYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRSGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDQPKHFSIHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPYFTQTSYTTEVEENRIDVEILRMVVHDQDLPNTPHSKAVYTILKGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQIGVLNEAQFTNAANAQPPTMCTTTVTVKIKDRDEGPECQPPVKVIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMVGDEDNWFEINKITGDLRTVKVLDRESKFVKNNQYNISVVATDTAGRSCTGTLVVLLEDFNDHPPQIDKEVTICQQEKDFAVLEPIDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTTPTECRMAVKEERDAKPNIILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTANICDTSMSVGTLGGQGIKTQQSFEMVKGGHTLESHKGGVLGAAEPGRYAYTDWQTFTQPRLGEKVYLCGQAEEHKHCEDYVRPYNYEGKGSMAGSVGCCSDRQEEEGLEFLDQLEPKFRTLAKTCVKK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	Source
130	N-linked (GlcNAc...) asparagine		UniProt GlyGen
165	N-linked (GlcNAc...) asparagine		UniProt GlyGen
546	N-linked (GlcNAc...) (high mannose) asparagine	16170054	UniProt GlyGen
613	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Formation of the cornified envelope	Mus musculus
Keratinization	Mus musculus
Neutrophil degranulation	Mus musculus

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