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Melanocortin receptor 5

Summary

UniProt ID

P56451

Gene Symbol

MC5R

Gene ID

[507987]

Organism

Bos taurus (domestic cattle)

External Links

PubChem: P56451
Re-Glyco: P56451

Annotation

Keyword: Calcium Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Metal-binding Palmitate Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
temperature homeostasis	ISS	GO_REF
temperature homeostasis	IEA	GO_REF
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	GO_REF
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA	GO_REF
positive regulation of exocytosis	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response

regulation of immune response [inference]

negative regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response

negative regulation of response to stimulus [inference]

negative regulation of immune response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of immune response

regulation of immune response [inference]

negative regulation of immune response

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

Displaying **all 3** entries
GO Term	Evidence Code	Reference
cytoplasm	IBA	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
melanocortin receptor activity	IBA	GO_REF
melanocortin receptor activity	IEA	GO_REF GO_REF
corticotropin receptor activity	ISS	GO_REF
corticotropin receptor activity	IEA	GO_REF
melanocyte-stimulating hormone receptor activity	ISS	GO_REF

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

neuropeptide receptor activity [inference]

corticotropin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

neuropeptide receptor activity [inference]

corticotropin receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MNSSFHLHFLDLGLNTTDGNLSGLSVQNASSLCEDMGIAVEVFLALGLISLLENILVIGAIVRNRNLHTPMYFFVGSLAVADMLVSLSNSWETITIYLLTNKHLVMADASVRHLDNVFDSMICISVVASMCSLLAIAVDRYVTIFCALRYQRIMTGRRSGAIIGGIWAFCASCGTVFIVYYESTYVVICLIAMFLTMLLLMASLYTHMFLLARTHIRRIATLPGHSSVRQRTGVKGAITLAMLLGVFIVCWAPFFLHLILMISCPHNLYCSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQSFRTPCRFPSRY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
2	N-linked (GlcNAc...) asparagine	UniProt
15	N-linked (GlcNAc...) asparagine	UniProt
20	N-linked (GlcNAc...) asparagine	UniProt
28	N-linked (GlcNAc...) asparagine	UniProt