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Pro-neuregulin-2, membrane-bound isoform

Summary

UniProt ID: P56974
Gene Symbol: Nrg2
Gene ID
Organism: Mus musculus (house mouse)

External Links

GlyConnect

Pro-neuregulin-2, membrane-bound isoform

GlyGen

P56974

PubChem

P56974

Re-Glyco

P56974

Annotation

Keyword: Alternative splicing Cell membrane Disulfide bond EGF-like domain Glycoprotein Growth factor Immunoglobulin domain Reference proteome Secreted Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
cell surface receptor signaling pathway	IDA	PMID
epidermal growth factor receptor signaling pathway	ISO	GO_REF
nervous system development	IEA	GO_REF
intracellular signal transduction	IBA	GO_REF
ERBB4 signaling pathway	ISO	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

animal gross anatomical part developmental process [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of synapse maturation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

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GO Term	Evidence Code	Reference
extracellular region	ISO	PMID
extracellular region	TAS	Reactome
extracellular region	IDA	PMID PMID PMID
extracellular region	IPI	PMID
extracellular region	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

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GO Term	Evidence Code	Reference
epidermal growth factor receptor activity	ISO	GO_REF
signaling receptor binding	IBA	GO_REF
signaling receptor binding	IEA	GO_REF
epidermal growth factor receptor binding	ISO	GO_REF
growth factor activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

binding [inference]

protein binding [inference]

signaling receptor binding

ErbB-3 class receptor binding

growth factor receptor binding [inference]

epidermal growth factor receptor binding

ErbB-4 class receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVRVEDAGEYVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGSGPGADMQRSYDSYYYPAAGPGPRRSACALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPTRAKQDSGPL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
55	N-linked (GlcNAc...) asparagine		G86182NS	UniProt GlyGen
186	N-linked (GlcNAc...) asparagine	30899004	G42124LM G05724UK	UniProt GlyGen GlyConnect
254	N-linked (GlcNAc...) asparagine		G39446WN	UniProt GlyGen
296	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 15 in total

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Pathway Name	Organism
Downregulation of ERBB2 signaling	Mus musculus
Downregulation of ERBB2:ERBB3 signaling	Mus musculus
ERBB2 Activates PTK6 Signaling	Mus musculus
ERBB2 Regulates Cell Motility	Mus musculus
GRB2 events in ERBB2 signaling	Mus musculus
GRB7 events in ERBB2 signaling	Mus musculus
PI3K events in ERBB2 signaling	Mus musculus
PI3K events in ERBB4 signaling	Mus musculus
PI3K/AKT Signaling	Mus musculus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Mus musculus

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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