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Repository for lectin-assisted multimodality data
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Nicastrin
Summary
- UniProt ID
- P57716
- Gene Symbol
-
- Ncstn
- Gene ID
- 59287
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Cytoplasmic vesicle
- Disulfide bond
- Glycoprotein
- Notch signaling pathway
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi apparatus |
| sarcolemma |
| lysosomal membrane |
| synaptic vesicle |
| presynaptic membrane |
| gamma-secretase complex |
| GO Term |
|---|
| growth factor receptor binding |
| peptidase activity |
| protein-macromolecule adaptor activity |
| ATPase binding |
Sequence
MATTRGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLKWVLTDGPNPPYMVLLEGKLFTRDVMEKLKGTTSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSVGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLSRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLDLWMHTDPMSQKNESVKNQVEDLLATLEKSGAGVPEVVLRRLAQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPEWQSPEEDLNFVTDTAKALANVATVLARALYELAGGTNFSSSIQADPQTVTRLLYGFLVRANNSWFQSILKHDLRSYLDDRPLQHYIAVSSPTNTTYVVQYALANLTGKATNLTREQCQDPSKVPNESKDLYEYSWVQGPWNSNRTERLPQCVRSTVRLARALSPAFELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSTLVFSLIVTYCINAKADVLFVAPREPGAVSY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 529 | N-linked (GlcNAc...) asparagine | |||
| 561 | N-linked (GlcNAc...) asparagine | |||
| 572 | N-linked (GlcNAc...) asparagine | |||
| 579 | N-linked (GlcNAc...) asparagine | |||
| 593 | N-linked (GlcNAc...) asparagine |
|
||
| 611 | N-linked (GlcNAc...) asparagine |
|
G70101JE
G80920RR
G64527OM
G05724UK
G34071NT
G82449NI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| EPH-ephrin mediated repulsion of cells | Mus musculus |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | Mus musculus |
| NRIF signals cell death from the nucleus | Mus musculus |
| Neutrophil degranulation | Mus musculus |
| Noncanonical activation of NOTCH3 | Mus musculus |
| Nuclear signaling by ERBB4 | Mus musculus |
| Regulated proteolysis of p75NTR | Mus musculus |
| TGFBR3 PTM regulation | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11054 | urinary bladder cancer | |
| DOID:5419 | schizophrenia | |
| DOID:8552 | chronic myeloid leukemia |
