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Dedicator of cytokinesis protein 4

Summary

UniProt ID

P59764

Gene Symbol

Dock4
Kiaa0716

Gene ID

[238130]

Organism

Mus musculus (house mouse)

External Links

GlyGen: P59764
The O-GlcNAc Database: P59764
O-GlcNAcAtlas: P59764
Re-Glyco: P59764

Annotation

Keyword: Alternative splicing Cell membrane Cytoplasm Guanine-nucleotide releasing factor Phosphoprotein Reference proteome SH3 domain SH3-binding

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
small GTPase-mediated signal transduction	IEA	GO_REF
cell chemotaxis	ISS	GO_REF
cell chemotaxis	ISO	GO_REF
cell chemotaxis	IBA	GO_REF
regulation of postsynapse assembly	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction

cell motility [inference]

cell migration [inference]

cell chemotaxis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
nucleolus	ISO	GO_REF
cytoplasm	IBA	GO_REF
Golgi apparatus	ISO	GO_REF
cytosol	ISS	GO_REF
cytosol	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular membraneless organelle [inference]

nucleolus

postsynapse

cluster of actin-based cell projections [inference]

stereocilium bundle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
guanyl-nucleotide exchange factor activity	ISS	GO_REF
guanyl-nucleotide exchange factor activity	ISO	GO_REF
guanyl-nucleotide exchange factor activity	IBA	GO_REF
guanyl-nucleotide exchange factor activity	IEA	GO_REF
GTPase activator activity	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor tyrosine kinase binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

GTPase binding [inference]

small GTPase binding

protein domain specific binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWIPTEHEKYGVVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPERHCSLFVDLGSSELRKDIYITVHIIRIGRMGAGEKKNACSVQYRRPFGCAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSDIIMPGEMRNDLYITVERGEFEKGGKSVARNVEVTMFIVDSNGQPLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGSHIRFEFRHCSTKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTTRYLKLPFSKVIFLGNNNQTMKATKESFWITSFLCSTKLTQNGDMLDLLKWRTHPDKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRDLIKVLKWYVDRITEAERQEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGTGALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQASSSAMRLQFQDVTGEFVACLLSLLRQMTDRHYQQLLNSFSTKEELRDFLLQIFTVFRILIRPEMFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATVTRLMERLLDYRDCMKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGAKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYNSPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVPVPVPVPVPVPVPSFSGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEPPALPPKPLAARSSHLENGTRRTEPGPRPRPLPRKVSQL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	PubMed ID	GlyTouCan ID	Source
1738			GlyGen
1773			GlyGen
1796	22517741 22645316 33300544 34678516 36852467 40021952 40885482	G49108TO	The O-GlcNAc Database
1806	22517741 22645316 33300544 34678516 36852467 40021952 40885482	G49108TO	GlyGen The O-GlcNAc Database
1916		G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Factors involved in megakaryocyte development and platelet production	Mus musculus
RAC1 GTPase cycle	Mus musculus
RAC2 GTPase cycle	Mus musculus
RHOG GTPase cycle	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements