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Lysine-specific demethylase 2A

Summary

UniProt ID: P59997
Gene Symbol: Kdm2a Fbl11 Fbxl11 Jhdm1a Kiaa1004
Gene ID: 225876
Organism: Mus musculus (house mouse)

External Links

GlyGen: P59997
Re-Glyco: P59997

Annotation

Keyword: 3D-structure ADP-ribosylation Allosteric enzyme Alternative splicing Biological rhythms Chromatin regulator Chromosome DNA-binding Dioxygenase Iron Isopeptide bond Leucine-rich repeat Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription regulation Ubl conjugation Ubl conjugation pathway Zinc-finger

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
in utero embryonic development	IMP	PMID
neural tube closure	IMP	PMID
neural tube closure	IEA	GO_REF
heart looping	IMP	PMID
double-strand break repair via nonhomologous end joining	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

multicellular organism growth

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation

growth [inference]

developmental growth [inference]

multicellular organism growth

rhythmic process [inference]

circadian rhythm [inference]

circadian regulation of gene expression

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

biological regulation [inference]

regulation of biological process [inference]

regulation of circadian rhythm

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying **all 3** entries
GO Term	Evidence Code	Reference
chromatin	IDA	PMID PMID
nucleoplasm	ISO	GO_REF
nucleoplasm	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
transcription coregulator activity	IBA	GO_REF
zinc ion binding	ISS	GO_REF
zinc ion binding	ISO	GO_REF
zinc ion binding	IEA	GO_REF
histone demethylase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

demethylase activity [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

catalytic activity, acting on a protein [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

histone modifying activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

sequence-specific DNA binding [inference]

unmethylated CpG binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

transcription regulator activity [inference]

transcription coregulator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQWPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLISVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKDFQKESLSMDMELNELESGNGDEEGVDREARRMNNKRSVLTSPVANGVNLDYDGLGKACRSLPSLKKTLSGDSSSDSTRGSHNGQVWDPQCSPKKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELASSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSDKAQKRKIEESDEEAVQAKVLRPLRSCEEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRPNPRVLMQHCPARNPQHGDEEGLGGEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRKELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPTDKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLFFLRRIANVTLIDLRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
132				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
HDMs demethylate histones	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements