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Integrin alpha-L

Summary

UniProt ID: P61625
Gene Symbol: ITGAL
Gene ID: 281874
Organism: Bos taurus (domestic cattle)

External Links

PubChem: P61625
Re-Glyco: P61625

Annotation

Keyword: Calcium Cell adhesion Cell membrane Disulfide bond Glycoprotein Integrin Magnesium Metal-binding Phagocytosis Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IEA	GO_REF
phagocytosis
heterophilic cell-cell adhesion	IEA	GO_REF
leukocyte cell-cell adhesion	IEA	GO_REF GO_REF
cell-matrix adhesion	IEA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte migration [inference]

cellular extravasation [inference]

T cell extravasation [inference]

memory T cell extravasation

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration [inference]

T cell extravasation [inference]

memory T cell extravasation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

cellular extravasation [inference]

T cell extravasation [inference]

memory T cell extravasation

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration [inference]

T cell extravasation [inference]

memory T cell extravasation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	Reference
cell surface	IBA	GO_REF
cell surface	IEA	GO_REF GO_REF
integrin alphaL-beta2 complex	IBA	GO_REF
integrin alphaL-beta2 complex	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex [inference]

integrin alphaL-beta2 complex

protein complex involved in cell adhesion [inference]

integrin complex [inference]

integrin alphaL-beta2 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex [inference]

integrin alphaL-beta2 complex

cellular anatomical structure [inference]

cell surface

Displaying **all 4** entries
GO Term	Evidence Code	Reference
ICAM-3 receptor activity	IEA	GO_REF
signaling receptor activity	IBA	GO_REF
metal ion binding
cell adhesion molecule binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cell adhesion molecule binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

ICAM-3 receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MNSCIIVLRLLLSGPFVFAPAWSYNLDVRHVQNFSFPLAGRHFGYRVLQVGNGVVVGAPSEGNSMGNLYQCQPETGDCLPVTLSSNYTSKYLGMTLATDPTSDNLLACDPGLSRTCDQNIYLSGLCYLIHENLRGPVLQGHPGYQECIKGNVDLVFLFDGSMSLQQDEFEKIVDFMKDVMKKLSNSSYQFAAVQFSTYFRTEFTFLDYIRQKDPDALLAGVKHMRLLTNTFGAINYVAKEVFRPDLGARPDATKVLIIITDGEATDEHNIDAAKDIIRYIIGIGKNFKTKESQEALHQFASKPVEEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSEGHGVVGAVGAKDWAGGFLDLKADLKSSTFVGNEPLTVESRAGYLGYTVTWLPSRGTMSLLATGAPRYQHVGRVLLFQQPKRGGPWSQIQEIDGIQIGSYFGGELCGVDVDRDGETELLLIAAPLYYGEQRGGRVFIYQKIQLEFQMVSELQGETGYPLGRFGAAIAALTDINGDELTDVAVGAPLEEQGAVYIFNGQQGGLSPRPSQRIEGTQMFSGIQWFGRSIHGVKDLGGDGLADVAVGAEGQVIVLSSRPVVDIITSVSFSPAEIPVHEVECSYSTSNQKKEGVNLTVCFQVKSLISTFQGHLVANLTYTLQLDGHRTRSRGLFPGGKHKLIGNTAVTPVKSCFVFWFHFPICIQDLISPINVSLSYSLWEEEGTPRDPRALDRDIPPILKPSPHLETKEIPFEKNCGEDKNCEADLKLAFSDMRSKILRLTPSASLSVRLTLRNTAEDAYWVQVTLSFPQGLSFRKVEILKPHSHVPVGCEELPEEAVVHSRALSCNVSSPIFGEDSMVDIQVMFNTLQKGSWGDFIELQANVSCNNEDSSLLEDNSATTSIPVMYPINVLTKDQENSTLYISFTPKSPKIHHVKHIYQVRIQPSNYDNMPPLEALVRVPRVHSEGLITHKWSIQMEPPVNCSPRNLESPSDEAESCSFGTEFRCPIDFRQEILVQVNGMVELRGTIKASSMLSLCSSLAISFNSSKHFHLYGRNASMAQVVMKVDLVYEKEMLYLYVLSGIGGLLLLFLIFIALYKVGFFKRNLKEKMEANVDASSEIPGEDAGQPELEKECKDPGCLEPLQKTDEDGSGGD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 11 in total

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Position	Description	Source
33	N-linked (GlcNAc...) asparagine	UniProt
86	N-linked (GlcNAc...) asparagine	UniProt
185	N-linked (GlcNAc...) asparagine	UniProt
646	N-linked (GlcNAc...) asparagine	UniProt
667	N-linked (GlcNAc...) asparagine	UniProt
723	N-linked (GlcNAc...) asparagine	UniProt
859	N-linked (GlcNAc...) asparagine	UniProt
894	N-linked (GlcNAc...) asparagine	UniProt
929	N-linked (GlcNAc...) asparagine	UniProt
1056	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Cell surface interactions at the vascular wall	Bos taurus
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Bos taurus
Integrin cell surface interactions	Bos taurus
Neutrophil degranulation	Bos taurus

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