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Gamma-aminobutyric acid receptor subunit beta-3

Summary

UniProt ID: P63079
Gene Symbol: Gabrb3 Gabrb-3
Gene ID: 24922
Organism: Rattus norvegicus (Norway rat)

External Links

GlyGen: P63079
PubChem: P63079
Re-Glyco: P63079

Annotation

Keyword: Cell membrane Chloride channel Cytoplasmic vesicle Disulfide bond Glycoprotein Ligand-gated ion channel Postsynaptic cell membrane Receptor Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
gamma-aminobutyric acid signaling pathway	ISS	GO_REF
gamma-aminobutyric acid signaling pathway	ISO	GO_REF
gamma-aminobutyric acid signaling pathway	NAS	PMID
nervous system development	ISO	GO_REF
brain development	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

cellular developmental process [inference]

cell development [inference]

neuron development

inner ear receptor cell development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to nitrogen compound [inference]

cellular response to histamine

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

synapse organization [inference]

synapse assembly [inference]

inhibitory synapse assembly

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

behavior [inference]

learning or memory [inference]

rhythmic behavior [inference]

circadian behavior [inference]

circadian sleep/wake cycle process [inference]

circadian sleep/wake cycle, REM sleep

innervation

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development

inner ear receptor cell development

system development [inference]

nervous system development

animal gross anatomical part developmental process [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell development [inference]

neuron development

inner ear receptor cell development

rhythmic process [inference]

circadian rhythm [inference]

circadian behavior [inference]

circadian sleep/wake cycle process [inference]

circadian sleep/wake cycle, REM sleep

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to chemical [inference]

response to xenobiotic stimulus

response to metal ion [inference]

response to zinc ion [inference]

cellular response to zinc ion

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to nitrogen compound [inference]

cellular response to histamine

response to anesthetic

response to nitrogen compound [inference]

response to histamine [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to histamine

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to nitrogen compound [inference]

cellular response to histamine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

inhibitory postsynaptic potential

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
cytoplasm	IDA	PMID
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	EXP	PMID PMID PMID
plasma membrane	IDA	PMID PMID PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

GABA receptor complex [inference]

GABA-A receptor complex

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

sperm head

presynapse [inference]

terminal bouton

postsynapse [inference]

dendritic spine

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GO Term	Evidence Code	Reference
GABA-A receptor activity	ISO	GO_REF
GABA-A receptor activity	TAS	PMID
GABA-A receptor activity	IDA	PMID PMID PMID PMID
GABA-A receptor activity	IBA	GO_REF
GABA-A receptor activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

histamine binding

heterocyclic compound binding [inference]

histamine binding

protein-containing complex binding [inference]

AP-2 adaptor complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

GABA receptor activity [inference]

GABA-A receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWGFAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSEINRVDAHGNILLAPMDVHNEMNEVAGSVGDTRNSAISFDNSGIQYRKQSMPKEGHGRYMGDRSIPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
33	N-linked (GlcNAc...) asparagine			UniProt GlyGen
105	N-linked (GlcNAc...) asparagine	34106099	G02815KT	UniProt GlyGen
174	N-linked (GlcNAc...) asparagine			UniProt GlyGen