GlyCosmos Portal

Submissions

Actin, alpha skeletal muscle

Summary

UniProt ID: P68133
Gene Symbol: ACTA ACTA1
Gene ID: 58
Organism: Homo sapiens (human)

External Links

PubChem: P68133
The O-GlcNAc Database: P68133
RaftProt: P68133
O-GlcNAcAtlas: P68133
Re-Glyco: P68133

Annotation

Keyword: 3D-structure ATP-binding Acetylation Cytoskeleton Disease variant Hydrolase Isopeptide bond Methylation Muscle protein Nemaline myopathy Oxidation Proteomics identification Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	Reference
muscle contraction	TAS	PMID
positive regulation of gene expression	ISS	GO_REF
skeletal muscle thin filament assembly	IMP	PMID
skeletal muscle thin filament assembly	IBA	GO_REF
skeletal muscle fiber development	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

striated muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization [inference]

skeletal muscle thin filament assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

tissue migration [inference]

mesenchyme migration

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

striated muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

striated muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

Displaying entries **1 - 5** of 16 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	Reference
stress fiber	IDA	PMID
stress fiber	IBA	GO_REF
obsolete extracellular space
cytosol	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
striated muscle thin filament	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

myofilament [inference]

striated muscle thin filament

actomyosin [inference]

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	Reference
structural constituent of cytoskeleton	TAS	PMID
structural constituent of cytoskeleton	IBA	GO_REF
ATP binding	TAS	PMID
hydrolase activity
myosin binding	TAS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

myosin binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	PubMed ID	GlyTouCan ID	Source
262	23271734 23301498 26374642 29351928 30397120 30444036 33214551 34019948 37217939 40596516	G49108TO	The O-GlcNAc Database
267	23271734 23301498 26374642 29351928 30397120 30444036 33214551 34019948 37217939 40596516	G49108TO	The O-GlcNAc Database
273	23271734 23301498 26374642 29351928 30397120 30444036 33214551 34019948 37217939 40596516	G49108TO	The O-GlcNAc Database
280	23271734 23301498 26374642 29351928 30397120 30444036 33214551 34019948 37217939 40596516	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Activation of STAT3 by cadherin engagement	Homo sapiens
Formation of the dystrophin-glycoprotein complex (DGC)	Homo sapiens
Regulation of CDH1 Function	Homo sapiens
Striated Muscle Contraction	Homo sapiens

Human Protein Atlas

ENSG00000143632

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0081340	congenital myopathy 2C	Alliance of Genome Resources
DOID:0081339	congenital myopathy 2B	Alliance of Genome Resources
DOID:0110927	nemaline myopathy 3	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements