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Tubulin alpha-1A chain

Summary

UniProt ID

P68369

Gene Symbol

Tuba1
Tuba1a

Gene ID

[22142]

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003747
GlyGen: P68369
PubChem: P68369
RaftProt: P68369
Re-Glyco: P68369

Annotation

Keyword: 3D-structure Acetylation Cytoskeleton Direct protein sequencing Flagellum GTP-binding Hydrolase Isopeptide bond Magnesium Metal-binding Methylation Microtubule Nitration Phosphoprotein Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	Reference
microtubule cytoskeleton organization	IMP	PMID PMID PMID
mitotic cell cycle	IBA	GO_REF
neuron migration	IMP	PMID PMID PMID PMID PMID
startle response	IMP	PMID
'de novo' protein folding	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

'de novo' protein folding

microtubule-based process [inference]

microtubule cytoskeleton organization

microtubule polymerization or depolymerization [inference]

microtubule polymerization

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

transport along microtubule [inference]

organelle transport along microtubule

microtubule organizing center organization [inference]

centrosome cycle

cell cycle [inference]

mitotic cell cycle

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cell cycle process [inference]

centrosome cycle

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

central nervous system neuron differentiation [inference]

pyramidal neuron differentiation

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

cell migration [inference]

neuron migration

sperm motility [inference]

flagellated sperm motility

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

microtubule polymerization or depolymerization [inference]

microtubule polymerization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

neuron projection arborization

microtubule organizing center organization [inference]

centrosome cycle

cell junction organization [inference]

synapse organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

supramolecular fiber organization [inference]

microtubule polymerization

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

neuromuscular process [inference]

startle response

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

locomotory behavior

visual behavior [inference]

visual learning

adult behavior

adult locomotory behavior

exploration behavior [inference]

locomotory exploration behavior

motor behavior

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

neuron projection arborization

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

central nervous system neuron differentiation [inference]

pyramidal neuron differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

response to stimulus [inference]

response to external stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to mechanical stimulus

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to L-glutamate

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

response to peptide [inference]

response to cytokine [inference]

response to tumor necrosis factor

response to nitrogen compound [inference]

response to L-glutamate

response to oxygen-containing compound [inference]

response to L-glutamate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

protein transport [inference]

intracellular protein transport

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

microtubule-based transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

establishment of organelle localization [inference]

organelle transport along microtubule

organelle localization [inference]

establishment of organelle localization [inference]

organelle transport along microtubule

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

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GO Term	Evidence Code	Reference
condensed chromosome	IDA	PMID
cytoplasm
cytosol	IDA	PMID
microtubule	ISO	GO_REF
microtubule	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

neuromuscular junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

cilium

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome [inference]

condensed chromosome

cytoskeleton [inference]

microtubule cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular membraneless organelle [inference]

chromosome [inference]

condensed chromosome

cytoskeleton [inference]

microtubule cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

cytoplasmic microtubule

axonemal microtubule

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GO Term	Evidence Code	Reference
structural constituent of cytoskeleton	IBA	GO_REF
structural constituent of cytoskeleton	IEA	GO_REF
GTP binding	IMP	PMID
GTP binding	IBA	GO_REF
GTP binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

protein dimerization activity [inference]

protein heterodimerization activity

protein-folding chaperone binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
380			G01650EU	GlycoProtDB GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
AURKA Activation by TPX2	Mus musculus
Aggrephagy	Mus musculus
Anchoring of the basal body to the plasma membrane	Mus musculus
COPI-dependent Golgi-to-ER retrograde traffic	Mus musculus
COPI-independent Golgi-to-ER retrograde traffic	Mus musculus
COPI-mediated anterograde transport	Mus musculus
Carboxyterminal post-translational modifications of tubulin	Mus musculus
Cargo trafficking to the periciliary membrane	Mus musculus
EML4 and NUDC in mitotic spindle formation	Mus musculus
HSP90 chaperone cycle for SHRs	Mus musculus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:2490	congenital nervous system abnormality	Alliance of Genome Resources
DOID:0050453	lissencephaly	Alliance of Genome Resources

GlyTouCan

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