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Rho-associated protein kinase 2

Summary

UniProt ID: P70336
Gene Symbol: Rock2
Gene ID: 19878
Organism: Mus musculus (house mouse)

External Links

GlyConnect

Rho-associated protein kinase 2

GlyGen

P70336

Re-Glyco

P70336

Annotation

Keyword: ATP-binding Alternative splicing Biological rhythms Cell membrane Coiled coil Cytoskeleton Magnesium Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Zinc-finger

Gene Ontology (GO)

Displaying entries **1 - 5** of 71 in total

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GO Term	Evidence Code	Reference
mitotic cytokinesis	IBA	GO_REF
epithelial to mesenchymal transition	IGI	PMID
epithelial to mesenchymal transition	IEA	GO_REF
neural tube closure	IGI	PMID
response to ischemia	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway via death domain receptors

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway via death domain receptors

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

centrosome duplication

mitotic cell cycle process [inference]

mitotic cytokinesis

actin filament-based process [inference]

actin cytoskeleton organization

cortical actin cytoskeleton organization

actomyosin structure organization

stress fiber assembly

postsynaptic actin cytoskeleton organization

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to acetylcholine

cellular response to oxygen-containing compound [inference]

cellular response to acetylcholine

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cortical actin cytoskeleton organization

actomyosin structure organization

stress fiber assembly

postsynaptic actin cytoskeleton organization

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

host-mediated perturbation of symbiont process [inference]

host-mediated perturbation of viral process

rhythmic process

response to stimulus [inference]

response to stress [inference]

response to ischemia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to growth factor [inference]

response to transforming growth factor beta

response to chemical [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to acetylcholine

cellular response to oxygen-containing compound [inference]

cellular response to acetylcholine

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to angiotensin

cellular response to nitrogen compound [inference]

cellular response to acetylcholine

response to acetylcholine [inference]

cellular response to acetylcholine

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to angiotensin

cellular response to oxygen-containing compound [inference]

cellular response to acetylcholine

response to acetylcholine [inference]

cellular response to acetylcholine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to acetylcholine

cellular response to oxygen-containing compound [inference]

cellular response to acetylcholine

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of angiotensin-activated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to lysosome [inference]

negative regulation of protein localization to lysosome

negative regulation of protein localization [inference]

negative regulation of protein localization to lysosome

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of protein localization to endosome [inference]

regulation of protein localization to early endosome [inference]

positive regulation of protein localization to early endosome

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of circadian rhythm

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of centrosome duplication

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of tissue remodeling [inference]

positive regulation of connective tissue replacement

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

negative regulation of nitric oxide biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of bicellular tight junction assembly

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of protein localization [inference]

negative regulation of protein localization to lysosome

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of angiotensin-activated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to hypoxia

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of epidermal cell differentiation [inference]

regulation of keratinocyte differentiation

regulation of cell development [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

regulation of keratinocyte differentiation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of synapse maturation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of epidermal cell differentiation [inference]

regulation of keratinocyte differentiation

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway via death domain receptors

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway via death domain receptors

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of angiotensin-activated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

negative regulation of nitric oxide biosynthetic process

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of connective tissue growth factor production [inference]

positive regulation of connective tissue growth factor production

regulation of fibroblast growth factor production [inference]

positive regulation of fibroblast growth factor production

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization

RNA destabilization [inference]

mRNA destabilization

positive regulation of gene expression

positive regulation of cytokine production [inference]

negative regulation of gene expression

mRNA destabilization

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

negative regulation of nitric oxide biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization

RNA destabilization [inference]

mRNA destabilization

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of connective tissue growth factor production [inference]

positive regulation of connective tissue growth factor production

regulation of fibroblast growth factor production [inference]

positive regulation of fibroblast growth factor production

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization

RNA destabilization [inference]

mRNA destabilization

positive regulation of gene expression

positive regulation of cytokine production [inference]

negative regulation of gene expression

mRNA destabilization

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization

RNA destabilization [inference]

mRNA destabilization

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization

RNA destabilization [inference]

mRNA destabilization

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

positive regulation of centrosome duplication

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of cell junction assembly

negative regulation of cell junction assembly [inference]

negative regulation of bicellular tight junction assembly

regulation of bicellular tight junction assembly [inference]

negative regulation of bicellular tight junction assembly

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of epidermal cell differentiation [inference]

regulation of keratinocyte differentiation

regulation of cell development [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of centrosome duplication

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

negative regulation of nitric oxide biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

mRNA destabilization

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of bicellular tight junction assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

positive regulation of centrosome duplication

regulation of synapse organization [inference]

regulation of synapse maturation

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of bicellular tight junction assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of cell junction assembly

negative regulation of cell junction assembly [inference]

negative regulation of bicellular tight junction assembly

regulation of bicellular tight junction assembly [inference]

negative regulation of bicellular tight junction assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

positive regulation of centrosome duplication

positive regulation of cell cycle process [inference]

positive regulation of centrosome duplication

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of centrosome duplication

regulation of cellular response to stress [inference]

regulation of cellular response to hypoxia

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of connective tissue growth factor production [inference]

positive regulation of connective tissue growth factor production

regulation of fibroblast growth factor production [inference]

positive regulation of fibroblast growth factor production

regulation of tissue remodeling [inference]

positive regulation of tissue remodeling [inference]

positive regulation of connective tissue replacement

regulation of connective tissue replacement [inference]

positive regulation of connective tissue replacement

regulation of system process [inference]

regulation of nervous system process

regulation of muscle system process [inference]

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of tissue remodeling [inference]

positive regulation of connective tissue replacement

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of epidermal cell differentiation [inference]

regulation of keratinocyte differentiation

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization

RNA destabilization [inference]

mRNA destabilization

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF
nucleus	IEA	GO_REF
cytoplasm	ISO	GO_REF GO_REF
cytoplasm	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

microtubule organizing center [inference]

centrosome

spindle pole centrosome

cytosol

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

postsynaptic specialization [inference]

postsynaptic density

presynaptic active zone

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
protease binding	ISO	GO_REF
protein kinase activity	ISO	GO_REF
protein kinase activity	IDA	PMID
protein kinase activity	IEA	GO_REF
protein serine/threonine kinase activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

Rho-dependent protein serine/threonine kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

Rho-dependent protein serine/threonine kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

Rho-dependent protein serine/threonine kinase activity

protein serine kinase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

GTPase binding [inference]

small GTPase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

endopeptidase regulator activity [inference]

endopeptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSRPPPTGKMPGAPEAAPGDGAGAGRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYFRENLLLSDSPPCRENDAIQTRKSEESQEIQKKLYALEEHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEITLRKSVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQSSQISTEKVNQLQKQLDEANALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKTGKALLAKVELEKRQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADKNKIYESIEEAKSEAMKEMEKKLLEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDVRNLTLKIEQETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMKMNLEKQNTELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDTTIASLEETNRTLTSDVANLANEKEELNNKLKDSQEQLSKLKDEEMSAAAIKAQFEKQLLNERTLKTQAVNKLAEIMNRKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIGSGPGDAEPDDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
791		30899004	G50045TK G82119TF G29880MM G06110VR G14669DU G63628AV G32550BI	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
EPHB-mediated forward signaling	Mus musculus
G alpha (12/13) signalling events	Mus musculus
RHO GTPases Activate ROCKs	Mus musculus
RHOA GTPase cycle	Mus musculus
RHOB GTPase cycle	Mus musculus
RHOBTB1 GTPase cycle	Mus musculus
RHOC GTPase cycle	Mus musculus
RHOH GTPase cycle	Mus musculus
Sema4D induced cell migration and growth-cone collapse	Mus musculus
VEGFA-VEGFR2 Pathway	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements