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Phosphate-regulating neutral endopeptidase PHEX
Summary
- UniProt ID
- P70669
- Gene Symbol
-
- Hyp
- Pex
- Phex
- Gene ID
- 18675
- Organism
- Mus musculus (house mouse)
External Links
- Re-Glyco
- P70669
Annotation
- Keyword
-
- Biomineralization
- Cell membrane
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| endoplasmic reticulum |
| Golgi apparatus |
| perinuclear region of cytoplasm |
| GO Term |
|---|
| metal ion binding |
| metalloendopeptidase activity |
Sequence
MEAETGSTMETGKGTNRGIRIALALFIGGTLVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPRNSTMNRGADSCRLW
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 71 | N-linked (GlcNAc...) asparagine |
|
||
| 238 | N-linked (GlcNAc...) asparagine |
|
||
| 263 | N-linked (GlcNAc...) asparagine |
|
||
| 290 | N-linked (GlcNAc...) asparagine |
|
||
| 301 | N-linked (GlcNAc...) asparagine |
|
||
| 377 | N-linked (GlcNAc...) asparagine |
|
||
| 484 | N-linked (GlcNAc...) asparagine |
|
||
| 736 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050445 | X-linked hypophosphatemic rickets | |
| DOID:10754 | otitis media |
