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Phospholipid-transporting ATPase IA

Summary

UniProt ID: P70704
Gene Symbol: Atp8a1 Atpc1
Gene ID: 11980
Organism: Mus musculus (house mouse)

External Links

GlyGen

P70704

SwissLipids

SLP:000000333

RaftProt

P70704

Re-Glyco

P70704

Annotation

Keyword: ATP-binding Alternative splicing Cell membrane Cytoplasmic vesicle Endoplasmic reticulum Golgi apparatus Lipid transport Magnesium Metal-binding Phosphoprotein Reference proteome Translocase Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
learning	IMP	PMID
positive regulation of cell migration	IMP	PMID
phospholipid translocation	IBA	GO_REF
synaptic vesicle endocytosis	EXP	PMID
synaptic vesicle endocytosis	IEP	PMID

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

phospholipid transport [inference]

aminophospholipid transport [inference]

aminophospholipid translocation

phospholipid translocation

aminophospholipid translocation

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

organophosphate ester transport [inference]

phospholipid transport [inference]

aminophospholipid transport [inference]

aminophospholipid translocation

phospholipid translocation

aminophospholipid translocation

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

nitrogen compound transport [inference]

aminophospholipid transport [inference]

aminophospholipid translocation

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

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GO Term	Evidence Code	Reference
endoplasmic reticulum	ISS	GO_REF
endoplasmic reticulum	ISO	GO_REF
endoplasmic reticulum	IEA	GO_REF
Golgi apparatus	ISS	GO_REF
Golgi apparatus	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

phospholipid-translocating ATPase complex

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane [inference]

chromaffin granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane [inference]

chromaffin granule membrane

cell junction [inference]

synapse

glutamatergic synapse

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

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GO Term	Evidence Code	Reference
magnesium ion binding	IEA	GO_REF
ATP binding	IEA	GO_REF
ATP hydrolysis activity	IEA	GO_REF
phosphatidylserine floppase activity	ISO	GO_REF
phosphatidylserine floppase activity	EXP	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

intramembrane lipid carrier activity [inference]

ATPase-coupled intramembrane lipid carrier activity

flippase activity [inference]

aminophospholipid flippase activity [inference]

phosphatidylserine flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylserine flippase activity

floppase activity [inference]

phosphatidylserine floppase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular carrier activity [inference]

lipid carrier activity [inference]

intramembrane lipid carrier activity [inference]

ATPase-coupled intramembrane lipid carrier activity

flippase activity [inference]

aminophospholipid flippase activity [inference]

phosphatidylserine flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylserine flippase activity

floppase activity [inference]

phosphatidylserine floppase activity

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid carrier activity

flippase activity [inference]

aminophospholipid flippase activity [inference]

phosphatidylserine flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylserine flippase activity

floppase activity [inference]

phosphatidylserine floppase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLLSLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDIDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLHLHYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQSSQFGDEKTFNDPSLLDNLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVVVRTPSGKLRLYCKGADTVIYERLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFEEWRAVYHRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLKRNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTVFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAVPMAPDMSGEAAMLFSSGVFWVGLLSIPVASLLLDVLYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites