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MIRAGE
Disintegrin and metalloproteinase domain-containing protein 8
Summary
- UniProt ID
- P78325
- Gene Symbol
- ADAM8 MS2
- Gene ID
- 101
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Alternative splicing Disulfide bond EGF-like domain Glycoprotein Metal-binding Metalloprotease Proteomics identification Reference proteome Signal Transmembrane helix Zinc
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| cell morphogenesis | ||
| angiogenesis | ||
| leukocyte migration involved in inflammatory response | ||
| positive regulation of acute inflammatory response | ||
| positive regulation of cellular extravasation |
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of locomotion [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
positive regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| metalloendopeptidase activity | ||
| metalloendopeptidase activity | ||
| serine-type endopeptidase activity | ||
| calcium ion binding | ||
| metallopeptidase activity |
GO Hierarchy
Sequence
MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 67 |
|
|
||
| 91 |
|
|||
| 436 |
|
|
||
| 612 |
|
|
||
| 822 |
|
|
G80223IX
G84452RH
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Degradation of the extracellular matrix | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
