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MIRAGE
Protein jagged-1
Summary
- UniProt ID
- P78504
- Gene Symbol
- JAG1 JAGL1
- Gene ID
- 182
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011757
- GlyGen
- P78504
- PubChem
- P78504
- Re-Glyco
- P78504
Annotation
- Keyword
- 3D-structure Alternative splicing Calcium Cell membrane Charcot-Marie-Tooth disease Deafness Developmental protein Disease variant Disulfide bond EGF-like domain Glycoprotein Neurodegeneration Notch signaling pathway Proteomics identification Reference proteome Repeat Signal Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| angiogenesis | ||
| cell fate determination | ||
| negative regulation of cell-matrix adhesion | ||
| blood vessel remodeling |
|
|
| morphogenesis of an epithelial sheet |
|
|
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
negative regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of metabolic process [inference]
regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| extracellular region | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
| GO Term | Evidence Code | Reference |
|---|---|---|
| Notch binding | ||
| Notch binding | ||
| Notch binding | ||
| Notch binding | ||
| structural molecule activity |
GO Hierarchy
Sequence
MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQDNRDLESAQSLNRMEYIV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 86 |
|
|||
| 143 |
|
|
||
| 217 |
|
|||
| 370 |
|
|
||
| 382 |
|
|
||
| 559 |
|
|
||
| 585 |
|
|
||
| 597 |
|
|
||
| 745 |
|
|
||
| 960 |
|
|
G57321FI
G27058EU
G41071NU
G80920RR
G42124LM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | Homo sapiens |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| Nephron development | Homo sapiens |
| RAC1 GTPase cycle | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:6419 | tetralogy of Fallot | |
| DOID:9245 | Alagille syndrome | |
| DOID:1682 | congenital heart disease | |
| DOID:2377 | multiple sclerosis | |
| DOID:10595 | Charcot-Marie-Tooth disease |
