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Neuropilin-1

Summary

UniProt ID

P79795

Gene Symbol

NRP
NRP1

Gene ID

395560

Organism

Gallus gallus (chicken)

External Links

PubChem: P79795
Re-Glyco: P79795

Annotation

Keyword: Angiogenesis Calcium Cell adhesion Cell membrane Developmental protein Differentiation Disulfide bond Heparan sulfate Heparin-binding Metal-binding Mitochondrion Neurogenesis Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
vasculogenesis	IBA	GO_REF
neural crest cell migration	IBA	GO_REF
sprouting angiogenesis	IBA	GO_REF
cell adhesion
axon guidance	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

vascular endothelial growth factor receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cell migration in hindbrain [inference]

rhombomere cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell aggregation

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

sprouting angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

response to stimulus [inference]

response to stress [inference]

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

vascular endothelial growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	IDA	PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
focal adhesion	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

growth cone membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
vascular endothelial growth factor receptor activity	IBA	GO_REF
vascular endothelial growth factor receptor activity	IEA	GO_REF
heparin binding
semaphorin receptor activity	IBA	GO_REF
semaphorin receptor activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

vascular endothelial growth factor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

semaphorin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDWGLFLHCAALTFTLSRALRSDKCGDTIKILSPGYLTSPGYPQSYHPSQKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGDNAEGRLWGKYCGKIAPPPLVSSGPYLFIKFVSDYETHGAGFSIRYEVFKRGPECSRNFTSSSGMIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFELEPDSNTPGGAFCRYDRLEIWDGFPDVGPHIGRYCGQNNPGRVRSSTGILSMVFYTDSAIAKEGFSANYSVSQSSVSEDFQCMEPLGMESGEIHSDQITVSSQYSAIWSSERSRLNYPENGWTPGEDSVREWIQVDLGLLRFVSGIGTQGAISKETKKEYYLKTYRVDVSSNGEDWITLKEGNKPVVFQGNSNPTDVVYRPFPKPVLTRFVRIKPVSWENGVSLRFEVYGCKITDYPCSGMLGMVSGLIPDSQITASTQVDRNWIPENARLITSRSGWALPPTTHPYTNEWLQIDLGEEKIVRGIIVQGGKHRENKVFMKKFKIGYSNNGSDWKMIMDSSKKKIKTFEGNTNYDTPELRTFEPVSTRIIRVYPERATHAGLGLRMELLGCELEAPTAVPTVSEGKPVDECDDDQANCHSGTGGTTVLNTEKPTVIDNTVQPELPPYNLNCGFGWGSHKTLCQWEHDNQVDLKWAILTSKTGPIQDHTGDGNFIYSQADESQKGKVARLLSPIIYSQNSAHCMTFWYHMSGPHVGTLKIKLRYQKPDEYDQVLLSLNGHQANCWQEGRVLLHKSVKLYQVVIEGEIGKGNGGIAVDDINIDNHISQEDCQKSTDVESEIVEEDPESNQTGFTPSYRTDEDYDDISRKPGNVLKTLDPILITIIAMSALGVLLGAICGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQNSYSEA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
148	N-linked (GlcNAc...) asparagine	UniProt
259	N-linked (GlcNAc...) asparagine	UniProt
520	N-linked (GlcNAc...) asparagine	UniProt
610	O-linked (Xyl...) (chondroitin sulfate) serine; alternate O-linked (Xyl...) (heparan sulfate) serine; alternate	UniProt
817	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements