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MIRAGE
TGF-beta receptor type-1
Summary
- UniProt ID
- P80204
- Gene Symbol
- Tgfbr1
- Gene ID
- 29591
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- ATP-binding Apoptosis Cell membrane Differentiation Disulfide bond Glycoprotein Growth regulation Isopeptide bond Magnesium Manganese Metal-binding Phosphoprotein Receptor Reference proteome Serine/threonine-protein kinase Signal Tight junction Transmembrane helix Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| skeletal system development | ||
| angiogenesis | ||
| response to hypoxia | ||
| in utero embryonic development | ||
| kidney development |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cellular component biogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| protein kinase activity | ||
| protein kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| transmembrane receptor protein serine/threonine kinase activity |
GO Hierarchy
Sequence
MEAASAALRRCLLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 41 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downregulation of TGF-beta receptor signaling | Rattus norvegicus |
| TGF-beta receptor signaling activates SMADs | Rattus norvegicus |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | Rattus norvegicus |
| TGFBR3 regulates TGF-beta signaling | Rattus norvegicus |
| Ub-specific processing proteases | Rattus norvegicus |
