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Complement factor B

Summary

UniProt ID

P81187

Gene Symbol

Gene ID

[514076]

Organism

Bos taurus (domestic cattle)

External Links

PubChem: P81187
Re-Glyco: P81187

Annotation

Keyword: Cleavage on pair of basic residues Complement alternate pathway Direct protein sequencing Disulfide bond Glycoprotein Magnesium Metal-binding Reference proteome Repeat Secreted Serine protease Signal Sushi Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
proteolysis	IEA	GO_REF
complement activation	IEA	GO_REF
complement activation, alternative pathway	ISS	GO_REF
complement activation, alternative pathway	IBA	GO_REF
complement activation, alternative pathway	IEA	GO_REF GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, alternative pathway

activation of immune response [inference]

complement activation

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	IEA	GO_REF GO_REF
cell surface	ISS	GO_REF
cell surface	IEA	GO_REF
symbiont cell surface	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

other organism part [inference]

symbiont cell surface

Displaying **all 3** entries
GO Term	Evidence Code	Reference
serine-type endopeptidase activity	ISS	GO_REF
serine-type endopeptidase activity	IEA	GO_REF GO_REF
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGIGHNPRLCLVPLILGLLCGGVGMTPLPEAGPQSPCSLEGVEIKGGSFRLLKAGQVLEYLCPSGFYPYPTQIRTCRSTGSWSTLQTQDRKIVKRAECKAIRCPRPQDFENGEYWPRAAYYNLSDEISFRCYDGYTLRGSANRTCQGNGRWDGETAICDDGATYCPNPGIPLGTRKVGSQYRLEDRVTYYCNRGLTLRGSEQRTCLEGGSWSGTEPSCQDSFMYDTPAEVAEAFLSSLTETIEGVDAEDGHSPGEQQKRKIVLDPSGSMNIYLVLDGSDSVGAHNFTGAKNCLRDFIEKVASYGVKPKYGLVTYATEPKVLIRVSDPKSSEADWVTDQLNQINYADHKLKAGTNTKRALLEVYNMMSREVNQFKETWNRTRHVIIIMTDGLHNMGGDPVTVIHDIRYLLDIGRNRKNPREDYLDIYVFGVGPLVNQENINALASKKDKEKHVFKLQGMENLEDVFVQMLDESRTLGLCGMVWEHKDGTAYHKQPWQAKISVTRPSKGHESCMGAIVSEYFVLTAAHCFTVDDEKHSIKVSLGGQRKEWEVKEILFHPKYDLNAKKAKGIPEFYDYDVALVRLKEKLKYETTIRPICLPCTEGSIQALRLPRSTTCQQQMQELLPAKDIEALFVSESKKTLTRKAVYIKNGDKKASCERDALRAPGYEKVKDVSEVVTPRFLCTGGVDPYADPNTCKGDSGGPLIIHKRSRFIQVGVISWGVVDVCKRPQQVPGYARDFHINLYQVLPWLKEKLQNEDLGFL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
122	N-linked (GlcNAc...) asparagine	UniProt
142	N-linked (GlcNAc...) asparagine	UniProt
285	N-linked (GlcNAc...) asparagine	UniProt
378	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Activation of C3 and C5	Bos taurus
Alternative complement activation	Bos taurus
Regulation of Complement cascade	Bos taurus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements