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Prolyl endopeptidase FAP

Summary

UniProt ID: P97321
Gene Symbol: Fap
Gene ID: 14089
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003799
GlyGen: P97321
PubChem: P97321
The Human Metabolome Database: HMDBP13492
Re-Glyco: P97321

Annotation

Keyword: Alternative splicing Angiogenesis Apoptosis Cell adhesion Cell junction Cell membrane Cell projection Cleavage on pair of basic residues Disulfide bond Glycoprotein Reference proteome Secreted Serine protease Signal-anchor Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	Reference
angiogenesis
proteolysis	ISS	GO_REF
proteolysis	ISO	GO_REF
proteolysis	IBA	GO_REF
proteolysis	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

melanocyte apoptotic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

melanocyte proliferation

cell motility [inference]

cell migration [inference]

endothelial cell migration

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of collagen catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

negative regulation of extracellular matrix disassembly

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cell cycle

regulation of execution phase of apoptosis [inference]

positive regulation of execution phase of apoptosis

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GO Term	Evidence Code	Reference
obsolete extracellular space
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

leading edge membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
protease binding	ISO	GO_REF
protease binding	IEA	GO_REF
endopeptidase activity	ISO	GO_REF
endopeptidase activity	IEA	GO_REF
serine-type endopeptidase activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKTWLKTVFGVTTLAALALVVICIVLRPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYGDGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWVSSERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQDATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALVCYGPGLPISTLHDGRTDQEIQVLEENKELENSLRNIQLPKVEIKKLKDGGLTFWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYSERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCFSLSD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	GlyTouCan ID	Source
49	N-linked (GlcNAc...) asparagine	G02815KT	UniProt GlyGen
92	N-linked (GlcNAc...) asparagine		UniProt GlyGen
99	N-linked (GlcNAc...) asparagine		GlycoProtDB UniProt GlyGen
227	N-linked (GlcNAc...) asparagine		UniProt GlyGen
314	N-linked (GlcNAc...) asparagine		GlycoProtDB UniProt GlyGen
679	N-linked (GlcNAc...) asparagine	G01937VC	UniProt GlyGen