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Aminopeptidase N

Summary

UniProt ID: P97449
Gene Symbol: Anpep Lap-1 Lap1
Gene ID: 16790
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003812

GlyConnect

Aminopeptidase N

GlyGen

P97449

PubChem

P97449

RaftProt

P97449

Re-Glyco

P97449

Annotation

Keyword: Aminopeptidase Angiogenesis Cell membrane Developmental protein Differentiation Direct protein sequencing Disulfide bond Glycoprotein Metal-binding Metalloprotease Phosphoprotein Reference proteome Signal-anchor Sulfation Transmembrane helix Zinc

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
angiogenesis
angiotensin maturation	IMP	PMID
angiotensin maturation	IBA	GO_REF
angiotensin maturation	IEA	GO_REF
protein processing	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

catabolic process [inference]

peptide catabolic process

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

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GO Term	Evidence Code	Reference
obsolete extracellular space
endoplasmic reticulum-Golgi intermediate compartment	ISO	GO_REF
endoplasmic reticulum-Golgi intermediate compartment	IEA	GO_REF
plasma membrane	ISO	GO_REF GO_REF
plasma membrane	EXP	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum-Golgi intermediate compartment

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum-Golgi intermediate compartment

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	Reference
aminopeptidase activity	ISO	GO_REF
metallopeptidase activity	IMP	PMID
metallopeptidase activity	IEA	GO_REF
zinc ion binding	IEA	GO_REF
alanyl aminopeptidase activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

peptide binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAKGFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSATAPTLPGSTSATTATTTPAVDESKPWNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYRSEYMEGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVNTNTGEISQKHFLLDSKSNVTRPSEFNYIWIAPIPFLKSGQEDHYWLDVEKNQSAKFQTSSNEWILLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAISTACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIAFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKWFTENSS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
106	N-linked (GlcNAc...) asparagine	19349973 19656770 30899004	G05724UK G39188ZX G06110VR G66538GV G31596OQ	GlycoProtDB UniProt GlyGen GlyConnect
114	N-linked (GlcNAc...) asparagine	19349973 30899004	G43769HG G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
128	N-linked (GlcNAc...) asparagine	19656770 30899004	G64527OM G10486CT G72735IY G05724UK G39188ZX G06110VR G66538GV	GlycoProtDB UniProt GlyGen GlyConnect
234	N-linked (GlcNAc...) asparagine			UniProt GlyGen
288	N-linked (GlcNAc...) asparagine			UniProt GlyGen
318	N-linked (GlcNAc...) asparagine			UniProt GlyGen
332	N-linked (GlcNAc...) asparagine	19349973		UniProt GlyGen
573	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
606	N-linked (GlcNAc...) asparagine	19349973 19656770	G41071NU	GlycoProtDB UniProt GlyGen
624	N-linked (GlcNAc...) asparagine			UniProt GlyGen