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MIRAGE
Glutamate--cysteine ligase catalytic subunit
Summary
- UniProt ID
- P97494
- Gene Symbol
- Gclc Glclc
- Gene ID
- 14629
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
- ATP-binding Acetylation Glutathione biosynthesis Ligase Phosphoprotein Reference proteome
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| obsolete cysteine metabolic process |
|
|
| glutamate metabolic process | ||
| glutamate metabolic process | ||
| glutathione metabolic process | ||
| glutathione biosynthetic process |
GO Hierarchy
- response to activity
biological process
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| mitochondrion |
|
|
| cytosol | ||
| glutamate-cysteine ligase complex | ||
| glutamate-cysteine ligase complex | ||
| glutamate-cysteine ligase complex |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| magnesium ion binding | ||
| magnesium ion binding | ||
| magnesium ion binding | ||
| glutamate-cysteine ligase activity | ||
| glutamate-cysteine ligase activity |
Sequence
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAINKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDAEASKASQPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNRFRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLEEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCSKAQSSSEPAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYSLIWKCNQIADELCECPELLGSGFRKAKYSGGKSDPSA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 132 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Glutathione synthesis and recycling | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:83 | cataract |
