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Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Summary

UniProt ID: P97675
Gene Symbol: Enpp3 Npp3 Pdnp3
Gene ID: 54410
Organism: Rattus norvegicus (Norway rat)

External Links

Re-Glyco: P97675

Annotation

Keyword: 3D-structure ATP-binding Calcium Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Metal-binding Reference proteome Repeat Secreted Signal-anchor Transmembrane helix Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
basophil activation involved in immune response	ISS	GO_REF
basophil activation involved in immune response	ISO	GO_REF
pyrimidine nucleotide metabolic process	ISS	GO_REF
pyrimidine nucleotide metabolic process	ISO	GO_REF
phosphate-containing compound metabolic process	ISO	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine nucleotide metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine nucleotide metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine nucleotide metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine nucleotide metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleotide metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

homeostatic process [inference]

chemical homeostasis [inference]

inorganic ion homeostasis [inference]

phosphate ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of immune effector process [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of mast cell activation involved in immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of immune effector process [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mast cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of muscle cell differentiation [inference]

regulation of smooth muscle cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mast cell proliferation

regulation of leukocyte proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mast cell proliferation

regulation of mast cell proliferation [inference]

negative regulation of mast cell proliferation

regulation of cell differentiation [inference]

regulation of muscle cell differentiation [inference]

regulation of smooth muscle cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mast cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

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GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	ISO	GO_REF
extracellular region	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	Reference
nucleic acid binding	IEA	GO_REF
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISS	GO_REF
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISO	GO_REF
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IEA	GO_REF
phosphodiesterase I activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

phosphodiesterase I activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phosphodiesterase I activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

dinucleotide phosphatase activity

bis(5'-nucleosyl)-tetraphosphatase activity [inference]

bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity

bis(5'-adenosyl)-pentaphosphatase activity

nucleoside triphosphate diphosphatase activity

bis(5'-adenosyl)-triphosphatase activity

cyclic-GMP-AMP hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

phosphodiesterase I activity

binding [inference]

nucleic acid binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDSRLALATEEPIKKDSLKRYKILCAVLLALLVIVSLGLGLGLGLRKPEEHIGSCRKKCFDSSHRGLEGCRCDSGCTDRGDCCWDFEDTCVKSTQIWTCNSFRCGETRLEAALCSCADDCLQRKDCCTDYKAVCQGEVPWVTEACASSQEPQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNYSNSVPYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPEINFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRDLSCRKSDQHFKPYLTPDLPKRLHYAKNVRIDKVHLMVDRQWLAYRNKGSSNCEGGTHGYNNEFKSMEAIFLAHGPSFKEKTVIEPFENIEVYNLLCDLLHIQPAPNNGSHGSLNHLLKAPFYQPSHAEELSKSAGCGFTTPLPKDSLNCSCLALQTSGQEEQVNQRLNLSGGEVSATEKTNLPFGRPRVIQKNKDHCLLYHREYVSGFGKAMKMPMWSSYTVPKPGDTSSLPPTVPDCLRADVRVDPSESQKCSFYLADQNIDHGFLYPPAIKGNNESQYDALITSNLVPMYKEFKKMWDYFHKVLLIKYAIERNGVNVVSGPIFDYNYDGHFDAPDEITNYVAGTDVPVPTHYFVVLTSCKNKTHTPDSCPGWLDVLPFVVPHRPTNVESCPENKAEDLWVEERFKAHIARVRDVELLTGLDFYQEKTQPVSEILQLKTYLPTFETII

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	Source
237	N-linked (GlcNAc...) asparagine	UniProt
280	N-linked (GlcNAc...) asparagine	UniProt
289	N-linked (GlcNAc...) asparagine	UniProt
533	N-linked (GlcNAc...) asparagine	UniProt
574	N-linked (GlcNAc...) asparagine	UniProt
594	N-linked (GlcNAc...) asparagine	UniProt
702	N-linked (GlcNAc...) asparagine	UniProt
789	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements