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Protein smoothened

Summary

UniProt ID

P97698

Gene Symbol

Smo
Smoh

Gene ID

25273

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P97698
Re-Glyco: P97698

Annotation

Keyword

Cell membrane
Cell projection
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
9+0 non-motile cilium
dendrite
neuronal cell body
intracellular membrane-bounded organelle
postsynapse
late endosome
endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment
Golgi apparatus
centriole

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 94 in total

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GO Term
cell population proliferation
positive regulation of cell population proliferation
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell migration
epithelial cell differentiation
negative regulation of epithelial cell differentiation
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of vascular associated smooth muscle cell migration

Displaying **all 6** entries
GO Term
protein sequestering activity
patched binding
oxysterol binding
protein kinase A catalytic subunit binding
cAMP-dependent protein kinase inhibitor activity
G protein-coupled receptor activity

Annotation information from UniProt.

Sequence

MAAGRPVRGPELAPRRLLQLLLLVLLGGRGRGAALSGNVTGPGPRSAGGSARRNAPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFELNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANLWLVEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGEPCRQGAWTVVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAELLDADSDF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
38	N-linked (GlcNAc...) asparagine	UniProt
192	N-linked (GlcNAc...) asparagine	UniProt
497	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Activation of SMO	Rattus norvegicus
BBSome-mediated cargo-targeting to cilium	Rattus norvegicus
Hedgehog 'off' state	Rattus norvegicus
Hedgehog 'on' state	Rattus norvegicus

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources
DOID:4914	esophagus adenocarcinoma	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:9206	Barrett's esophagus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements