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Fumarate hydratase, mitochondrial

Summary

UniProt ID: P97807
Gene Symbol: Fh Fh1
Gene ID: 14194
Organism: Mus musculus (house mouse)

External Links

GlyGen: P97807
PubChem: P97807
Re-Glyco: P97807

Annotation

Keyword: Acetylation Alternative initiation Chromosome Cytoplasm DNA repair Direct protein sequencing Lyase Mitochondrion Nucleus Phosphoprotein Reference proteome Transit peptide Tricarboxylic acid cycle

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
urea cycle	IMP	PMID
obsolete regulation of arginine metabolic process
tricarboxylic acid cycle	IMP	PMID
tricarboxylic acid cycle	IBA	GO_REF
tricarboxylic acid cycle	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

urea cycle

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

arginine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

arginine metabolic process

urea metabolic process [inference]

urea cycle

nitrogen cycle metabolic process [inference]

urea metabolic process [inference]

urea cycle

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining [inference]

positive regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining [inference]

positive regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF
nucleus	IEA	GO_REF
cytoplasm	ISO	GO_REF
mitochondrion	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

site of DNA damage [inference]

site of double-strand break

Displaying **all 5** entries
GO Term	Evidence Code	Reference
fumarate hydratase activity	ISS	GO_REF
fumarate hydratase activity	ISO	GO_REF GO_REF
fumarate hydratase activity	IMP	PMID PMID
fumarate hydratase activity	IEA	GO_REF GO_REF GO_REF GO_REF GO_REF
histone binding	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

fumarate hydratase activity

binding [inference]

protein binding [inference]

histone binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MYRALRLLARSRRLLRVPSAGAAVSGEATTLPRCAPNVARMASQNSFRVEFDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIQAFGILKRAAAEVNQEYGLDPKIASAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPNDHVNKSQSSNDTFPTAMHIAAAVEVHKVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPLTLGQEFSGYVQQVQYAMVRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTAACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTDNCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites