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Complement component C8 alpha chain

Summary

UniProt ID

P98136

Gene Symbol

Gene ID

100009076

Organism

Oryctolagus cuniculus (rabbit)

External Links

PubChem: P98136
Re-Glyco: P98136

Annotation

Keyword: Calcium Complement alternate pathway Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Membrane attack complex Metal-binding Reference proteome Repeat Secreted Signal Target cell membrane Transmembrane beta strand

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
complement activation	ISS	GO_REF
complement activation	IEA	GO_REF
complement activation, alternative pathway
complement activation, classical pathway
killing of cells of another organism

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

cellular process [inference]

cell killing [inference]

killing of cells of another organism

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

Displaying **all 5** entries
GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	IEA	GO_REF GO_REF
membrane attack complex	ISS	GO_REF
membrane attack complex	IEA	GO_REF GO_REF
other organism cell membrane	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical structure [inference]

extracellular region

other organism part [inference]

other organism cell membrane

Displaying 1 entry
GO Term	Evidence Code	Reference
metal ion binding

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLVAAFFTLFLVTCQPAVTAQEKVNQRVNRAATPRAFDCQLSSWSEWTDCFPCQDTKYRHRSLLQPNKFGGTICSGDIWDRASCYSPTACLRPAQCGQDFQCKETGRCLKRHLVCNGENDCLDGSDEDNCEDIRATESDCAQYDPIPGSEKAALGYNILTQEEAQSVYDARYYGGRCETVYNGEWRHVRYDPVCERLHHGEDDKYFRKPYNFLKYHFEARADTGISFELYVDGNDLFSKVKNDKSHSAGVTISAGLTGSPLLGTVGVSGSEDASFLNKLSQYNEKKYNFMRIFTKVQTAHFKMRRDDIVLDEGMLQALVELPEQYNYGMYSKFINDYGTHYITSGSMGGTYEYILVLNTEKMESLGVTSEDISSCFGGFGEIQYEKGKINAQGILSGKHCKKSGSGDKEADKMGQAVKDIISRVRGGSSGWGGGLSQNGSATTYRFWGRSLKYNPVVIDFEMQPIHEVLLHTNLGHVEAKRQNLRRALDQYLMEFNACRCGPCFNNGKPILEGTSCRCQCSLGLQGPACEQTEQQGAKADGHWSCWGSWSPCTAGTRERRRECNNPAPQNGGAPCPGWRVQTQAC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
44	C-linked (Man) tryptophan	UniProt
438	N-linked (GlcNAc...) asparagine	UniProt
543	C-linked (Man) tryptophan	UniProt
546	C-linked (Man) tryptophan	UniProt
549	C-linked (Man) tryptophan	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements