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Endosomal/prevacuolar sodium/hydrogen exchanger

Summary

UniProt ID

Q04121

Gene Symbol

D9461.40
NHA2
NHX1
VPL27
VPS44
YDR456W

Gene ID

[852066]

Organism

Saccharomyces cerevisiae S288C

External Links

GlyGen: Q04121
PubChem: Q04121
Re-Glyco: Q04121

Annotation

Keyword: Antiport Endosome Glycoprotein Phosphoprotein Potassium transport Reference proteome Signal Sodium transport Transmembrane helix

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
vacuolar acidification	IMP	PMID
vacuolar acidification	IBA	GO_REF
intracellular monoatomic cation homeostasis	IMP	PMID
sodium ion transmembrane transport	IMP	PMID PMID
potassium ion transmembrane transport	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

intracellular monoatomic cation homeostasis

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
fungal-type vacuole membrane	IDA	PMID
fungal-type vacuole membrane	IBA	GO_REF
early endosome	IDA	PMID
early endosome	IBA	GO_REF
late endosome	IDA	PMID PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

fungal-type vacuole membrane

endosome membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 3** entries
GO Term	Evidence Code	Reference
sodium:proton antiporter activity	IMP	PMID PMID
sodium:proton antiporter activity	IEA	GO_REF
potassium:proton antiporter activity	IMP	PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

metal cation:proton antiporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

sodium ion transmembrane transporter activity [inference]

sodium:proton antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLSKVLLNIAFKVLLTTAKRAVDPDDDDELLPSPDLPGSDDPIAGDPDVDLNPVTEEMFSSWALFIMLLLLISALWSSYYLTQKRIRAVHETVLSIFYGMVIGLIIRMSPGHYIQDTVTFNSSYFFNVLLPPIILNSGYELNQVNFFNNMLSILIFAIPGTFISAVVIGIILYIWTFLGLESIDISFADAMSVGATLSATDPVTILSIFNAYKVDPKLYTIIFGESLLNDAISIVMFETCQKFHGQPATFSSVFEGAGLFLMTFSVSLLIGVLIGILVALLLKHTHIRRYPQIESCLILLIAYESYFFSNGCHMSGIVSLLFCGITLKHYAYYNMSRRSQITIKYIFQLLARLSENFIFIYLGLELFTEVELVYKPLLIIVAAISICVARWCAVFPLSQFVNWIYRVKTIRSMSGITGENISVPDEIPYNYQMMTFWAGLRGAVGVALALGIQGEYKFTLLATVLVVVVLTVIIFGGTTAGMLEVLNIKTGCISEEDTSDDEFDIEAPRAINLLNGSSIQTDLGPYSDNNSPDISIDQFAVSSNKNLPNNISTTGGNTFGGLNETENTSPNPARSSMDKRNLRDKLGTIFNSDSQWFQNFDEQVLKPVFLDNVSPSLQDSATQSPADFSSQNH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	Source
420	N-linked (GlcNAc...) asparagine		UniProt GlyGen
515	N-linked (GlcNAc...) asparagine	11036065	UniProt GlyGen
550	N-linked (GlcNAc...) asparagine	11036065	UniProt GlyGen
563	N-linked (GlcNAc...) asparagine	11036065	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Sodium/Proton exchangers	Saccharomyces cerevisiae

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements