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Proton-coupled folate transporter

Summary

UniProt ID

Q05B81

Gene Symbol

HCP1
PCFT
SLC46A1

Gene ID

[511097]

Organism

Bos taurus (domestic cattle)

External Links

PubChem: Q05B81
Re-Glyco: Q05B81

Annotation

Keyword: Acetylation Cell membrane Cytoplasm Disulfide bond Endosome Folate-binding Glycoprotein Phosphoprotein Reference proteome Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
folic acid transport	ISS	GO_REF
folic acid transport	IEA	GO_REF
heme transport	IDA	PMID
heme transport	IEA	GO_REF
tetrahydrofolate biosynthetic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate biosynthetic process

modified amino acid biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process

biosynthetic process [inference]

modified amino acid biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process

pteridine-containing compound biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate biosynthetic process

pteridine-containing compound biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process

transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

import across plasma membrane [inference]

folate import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

iron coordination entity transport [inference]

heme transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

folate transmembrane transport [inference]

folate import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

folate transmembrane transport [inference]

folate import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

vitamin transport [inference]

folic acid transport

folate transmembrane transport [inference]

folate import across plasma membrane

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

import across plasma membrane [inference]

folate import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

nitrogen compound transport [inference]

heme transport

modified amino acid transport [inference]

folic acid transport

folate transmembrane transport [inference]

folate import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

folate import across plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
cytoplasm	ISS	GO_REF
cytoplasm	IEA	GO_REF GO_REF
endosome	ISS	GO_REF
endosome	IEA	GO_REF
plasma membrane	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
folic acid binding
folic acid transmembrane transporter activity	ISS	GO_REF
folic acid transmembrane transporter activity	IEA	GO_REF
heme transmembrane transporter activity	IDA	PMID
heme transmembrane transporter activity	IEA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

solute:proton symporter activity [inference]

folic acid:proton symporter activity

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity [inference]

folic acid:proton symporter activity

heme transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity [inference]

folic acid:proton symporter activity

xenobiotic transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

folic acid transmembrane transporter activity

folic acid:proton symporter activity

modified amino acid transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folic acid:proton symporter activity

vitamin transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folic acid:proton symporter activity

binding [inference]

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

heterocyclic compound binding [inference]

folic acid binding

modified amino acid binding [inference]

folic acid binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEGRANSPGEPRAWPTRSVLCRGCVEPLVFLANFALVLQGPVTTQYLWHRFSADLGYNGTRHRDSCSNHSVDPIAQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDCVGRRPLLVLASLGLLLQTVLSIFVVQLHLHIGYLVLGRILCALLGDFSGLLAASFASVADVSSSRTRTIRMALLEACIGVAGMLASFIGGFLLQEQVYVNPFWLALAVLTVMTLYAAFCFGETVKERTPTRLFTLRHHRSVIQLYVTQAPEKSRKHLALYSLAIFVMITVHLGAQDILTLYELSAPLCWDSRLISYGSAAQQLPYLTSLLGLRLLQYCLADTWVAEIGLVFNILGMMVFAFATITPLMFTGYGLLFLSLVVTPIIRAKLSRLVRQSEQGALFSALACVNGLAMLMASGIFNSLYPATLNLMKGFPFLLAAGLLFIPAILMGILERDNHCPEFQEFSQSP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
58	N-linked (GlcNAc...) asparagine			UniProt
68	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Heme signaling	Bos taurus
Iron uptake and transport	Bos taurus
Metabolism of folate and pterines	Bos taurus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements