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Proheparin-binding EGF-like growth factor

Summary

UniProt ID

Q06175

Gene Symbol

Hbegf
Dtr
Hegfl

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q06175

Annotation

Keyword

Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Heparin-binding
Reference proteome
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 17 in total

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GO Term
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of keratinocyte migration
cell chemotaxis
positive regulation of wound healing
negative regulation of elastin biosynthetic process
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
epidermal growth factor receptor signaling pathway
wound healing, spreading of epidermal cells
ERBB2-EGFR signaling pathway

Displaying **all 3** entries
GO Term
cell surface
extracellular space
plasma membrane

Displaying **all 5** entries
GO Term
receptor ligand activity
epidermal growth factor receptor binding
growth factor activity
heparin binding
transmembrane receptor protein tyrosine kinase activator activity

Annotation information from UniProt.

Sequence

MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAATSNPDPPTGTTNQLLPTGADRAQEVQDLEGTDLDLFKVAFSSKPQALATPGKEKNGKKKRKGKGLGKKRDPCLKKYKDYCIHGECRYLKELRIPSCHCLPGYHGQRCHGLTLPVENPLYTYDHTTVLAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDLESEEKVKLGMASSH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
85	O-linked (GalNAc...) threonine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **21 - 24** of 24 in total

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Pathway Name	Organism
SHC1 events in ERBB4 signaling	Rattus norvegicus
Signaling by EGFR	Rattus norvegicus
Signaling by ERBB2	Rattus norvegicus
Signaling by ERBB4	Rattus norvegicus